Structural and spectral studies of N-(2-pyridyl)-N′-(4-substituted phenyl)thioureas
The following molecules were found to have intramolecular hydrogen bonding between the N′H and the pyridine nitrogen and intermolecular hydrogen bonding between the NH and a thione sulfur of a second molecule to form dimers: N-(2-pyridyl)-N′-(4-methoxyphe
Szczepura, Lisa F.,Eilts, Kristin K.,Hermetet, Ann K.,Ackerman, Lily J.,Swearingen, John K.,West, Douglas X.
p. 101 - 110
(2007/10/03)
Solvent-free synthesis of heterocyclic thioureas using microwave technology
A new and rapid solvent-free synthesis of heterocyclic thioureas in a microwave oven has been reported for the first time. Nine heterocyclic thioureas that possess biological activity have been synthesized. The reaction time is short (2-4.5 min) and gives
Li, Jian-Ping,Luo, Qian-Fu,Wang, Yu-Lu,Wang, Hong
p. 73 - 75
(2007/10/03)
Interactions between substituted thioureas and π-acceptors
Charge-transfer (CT) interactions between some N-aryl-N'-heterocyclic thioureas and both tetracyanoethylene (TCNE) and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) were investigated spectroscopically. The formed CT complexes and the solvent effect on CT complexation are discussed. N-Aryl-N'-(2-pyridyl)-thioureas 1 a-d reacted with TCNE to give cyanothiourea derivatives 6, however in case of DDQ, the adducts 7 were obtained.
Mohamed,Hassan,Ibrahim,Semida,Mourad
p. 592 - 595
(2007/10/02)
Anticonvulsant activity and succinate dehydrogenase inhibitory property of new substituted thiobarbiturates
Eight 1-aryl-3-(2-pyridyl)thiobarbiturates were synthesized and evaluated for their anticonvulsant property and their ability to inhibit succinate dehydrogenase activity of rat brain homogenates. These substituted thiobarbiturates (100 mg./kg., i.p.) provided 20-60% protection against pentylenetetrazol-induced convulsions in albino mice. Low toxicity of these compounds was reflected by their high approximate LD50 values which were found to range from 500-1000 mg/kg. All substituted thiobarbiturates (1mM) inhibited in vitro succinate dehydrogenase activity and the degree of inhibition ranged from 10-72%.
Dhasmana,Barthwal,Pandey,et al.
p. 635 - 637
(2007/10/02)
Biologically active thiazolidinone
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Gupta,Nath,Shanker,et al.
p. 832 - 834
(2007/10/04)
Synthesis of new unsymmetrical 1,3 disubstituted thioureas
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Singh
p. 1285 - 1286
(2007/10/04)
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