- Pyridazinedione compounds useful in treating neurological disorders
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The present invention relates to pyridazino[4,5-b]quinolines, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]quinolines as active ingredient, and methods for the treatment of neurological disorders.
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- Synthesis of a 6H-pyrazolo[4,5,1-de]acridin-6-one derivative: A useful intermediate of antitumour agents
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A 6H-pyrazolo[4,5,1-de]acridin-6-one derivative, a useful intermediate of antitumor agents, was prepared by a facile synthetic route from 2-bromobenzoic acid and 6-nitroindazole involving a halogenocopper(I)-catalyzed Ullmann coupling reaction and Friedel-Crafts cyclization.
- Sugaya,Mimura,Kato,Ikuta,Mimura,Kasai,Tomioka
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- 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS AND USE AS ENZYME INHIBITORS
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Novel 2-amino-4H-3,1-benzoxazin-4-ones represented by the formula wherein R 1, R 2, R 3 and X are defined herein are useful as enzyme inhibitors in animals.
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- Substituted benzoxazin-2-ones and pharmaceutical compositions containing them
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This invention is directed to novel benzoxazin-2-ones of the formula STR1 wherein A is a sulfur atom or an SO, SO2, R--N=S, or R--N=SO2 group where R is a hydrogen atom or an acyl group; D is an alkylene group; R1 is an al
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- An Improved Synthesis of 6-Methoxyanthranilic Acid
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6-Methoxyanthranilic acid (1) is prepared in three steps from 2,6-dinitrobenzoic acid (6) in an overall yield of 46percent.
- Warrener, Ronald N.,Russel, Richard A.,Marcuccio, Sebastian M.
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p. 2777 - 2779
(2007/10/02)
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