Novel heterocyclic compounds shown by the general formula STR1 or the pharmaceutically acceptable salts thereof useful as medicament in particular as antagonist of slow reacting substance of anaphylaxis (SRS-A).
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(2008/06/13)
New broad spectrum alkylthio cephalosporins
A series of 7 substituted alkyl thio acylaminocephalosporins were prepared and tested for in vitro antibacterial activity. The authors tried in their research to find any relationship between antibacterial activity and pharmacokinetic properties on the one hand, and chemical structure on the other. The most interesting products were also studied for their in vivo antibacterial activity in experimental acute systemic infections in the mouse.
Nannini,Molgora,Biasoli
p. 343 - 352
(2007/10/05)
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