- Study on a series of water-soluble photoinitiators for fabrication of 3D hydrogels by two-photon polymerization
-
A series of water-soluble benzylidene cyclanone dyes T1-T3 were synthesized. Their photo-physical properties were investigated using UV–Vis spectra, fluorescence spectra and two-photon absorption spectra. The maximum two-photon absorption cross-sections (σ2) of T1-T3 in deionized water were determined as 567?GM, 808?GM and 231?GM. Using T1-T3 as photoinitiators (PIs) directly, 2D and 3D nano patterns based on two-photon crosslinking or polymerization of bovine serum albumin (BSA), water-soluble acrylic ester monomer (SR610) and hyaluronic acid derivative (HAGM) were successfully fabricated, respectively. Much lower threshold energies and wider fabrication windows were obtained in the formulations containing these PIs compared with commercial ones. Furthermore, the cytotoxicity study showed a favorable biocompatibility of these PIs, which indicated T1-T3 would have application prospects in 3D fabrication of biomaterials.
- Huang, Xing,Wang, Xiaopu,Zhao, Yuxia
-
p. 413 - 419
(2017/03/24)
-
- Aza-Michael reaction: Selective mono- versus bis-addition under environmentally-friendly conditions
-
Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono- or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity.
- Bosica, Giovanna,Spiteri, Jonathan,Borg, Caroline
-
p. 2449 - 2454
(2014/04/03)
-
- Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA- methyltransferase, DNA mismatch repair, and p53
-
The antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C. 2.1.1.63, MGMT). Tumor response is also dependent on wild-type p53. Novel 3-(2-anilinoethyl)-substituted imidazotetrazines are reported that have activity independent of MGMT, MMR, and p53. This is achieved through a switch of mechanism so that bioactivity derives from imidazotetrazine-generated arylaziridinium ions that principally modify guanine-N7 sites on DNA. Mono- and bifunctional analogues are reported, and a quantitative structure-activity relationship (QSAR) study identified the p-tolyl-substituted bifunctional congener as optimized for potency, MGMT-independence, and MMR-independence. NCI60 data show the tumor cell response is distinct from other imidazotetrazines and DNA-guanine-N7 active agents such as nitrogen mustards and cisplatin. The new imidazotetrazine compounds are promising agents for further development, and their improved in vitro activity validates the principles on which they were designed.
- Pletsas, Dimitrios,Garelnabi, Elrashied A.E.,Li, Li,Phillips, Roger M.,Wheelhouse, Richard T.
-
p. 7120 - 7132
(2013/10/01)
-
- Solvent-promoted and -controlled Aza-Michael reaction with aromatic amines
-
(Chemical Equation Presented) 1,4-Addition of anilines onto Michael acceptors proceeds easily in specific polar protic solvents, without any promoting agent. According to the solvent and to the electrophile, the selectivity of the reaction can be finely tuned. With methyl acrylate as electrophile, only monoaddition takes place in water, while the diadduct is yielded in hexafluoroisopropyl alcohol (HFIP). The use of methyl vinyl ketone as a partner affords the monoadduct in water, the diadduct in trifluoroethanol (TFE), and the quinoline in HFIP.
- De, Kavita,Legros, Julien,Crousse, Benoit,Bonnet-Delpon, Daniele
-
experimental part
p. 6260 - 6265
(2009/12/06)
-
- An efficient ZrCl4 catalyzed aza-michael addition reaction: Synthesis of C-linked carbo β3-amino acids
-
A mild aza-Michael protocol has been developed using ZrCl4 as catalyst on α, β-unsaturated esters and nitriles. The aromatic amines were found to give the products with ease. The ZrCl4 mediated route was compatible with acid sensitive carbohydrate esters and provided an efficient method to prepare C-linked carbo β3-amino acids (β3-Caa).
- Damera, Krishna,Reddy, Katta L.,Sharma, Gangavaram V.M.
-
experimental part
p. 151 - 155
(2010/04/23)
-
- Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
-
The present invention encompasses compounds of Formula I: as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
- -
-
Page/Page column 40
(2009/04/24)
-
- Double-helix pattern in a model compound of non-linear optical polymers1
-
Molecules of the title compound, 3,3'-[4-(4-nitrophenyl-diazenyl) phenylimino]dipropionic acid, C18H18N4O 6 a model compound of second-order non-linear optically active polymers, form helicoidal rows via hydrogen bonding between carboxy groups. Pairs of helices are wrapped around the common axis in a double-helix arrangement unprecedented in dicarboxylic acids. The lateral packing of the helices shows an interdigitated antiparallel arrangement of the chromophore units.
- Centore, Roberto,Carella, Antonio,Pugliese, Andrea,Sirigu, Augusto,Tuzi, Angela
-
p. o531-o533
(2007/10/03)
-
- Cu(acac)2 immobilized in ionic liquids: A recoverable and reusable catalytic system for aza-Michael reactions
-
Copper(II) acetylacetonate immobilized in ionic liquids efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds to produce the corresponding β-amino carbonyl compounds with great alacrity in excellent yields. The reactions are far more facile than those reported earlier. The recovered ionic liquid phase containing the copper catalyst can be reused for several cycles with consistent activity.
- Kantam, M. Lakshmi,Neeraja,Kavita,Neelima,Chaudhuri, Mihir K.,Hussain, Sahid
-
p. 763 - 766
(2007/10/03)
-
