Discovery of dihydrooxazolo[2,3-: A] isoquinoliniums as highly specific inhibitors of hCE2
Human carboxylesterase 2 (hCE2) is one of the most abundant esterases distributed in human small intestine and colon, which participates in the hydrolysis of a variety of ester-bearing drugs and thereby affects the efficacy of these drugs. Herein, a new c