- Processes for preparing 7-carboxy substituted steroids
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This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C1-C6 alkyl or C1-C6 alkoxy; R3 is C1-C6 alkyl; Z1 is —CH2— or wherein O—COR4 is in the α configuration; Z2 is —CH—; or Z1 and Z2 may be taken together to form a carbon-carbon double bond; Q is These intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-α-epoxy-17-α-hydroxy-3-oxopregn-4-ene-α-7-21-dicarboxylic acid, γ-lactone, methyl ester (eplerenone; epoxymexrenone).
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- New process for the preparation of methyl carbonates
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(Matrix presented) The methyl carbonate of HOBt was developed for the conversion of alcohols to carbonates. This method is superior to the use of methyl chloroformate or methyl pyrocarbonate, especially with more hindered alcohols. The reagent is a stable solid that is easily prepared on a multigram scale.
- Wuts, Peter G. M.,Ashford, Scott W.,Anderson, Andrew M.,Atkins, Joseph R.
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p. 1483 - 1485
(2007/10/03)
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