The subject invention provides rasagiline citramide and a composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of rasagiline citramide or a salt thereof.
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Paragraph 0133; 0136; 0137
(2013/04/13)
Synthesis of citrate-ciprofloxacin conjugates
Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
Md-Saleh, Siti R,Chilvers, Emily C.,Kerr, Kevin G.,Milner, Stephen J.,Snelling, Anna M.,Weber, Jan P.,Thomas, Gavin H.,Duhme-Klair, Anne-Kathrin,Routledge, Anne
scheme or table
p. 1496 - 1498
(2009/11/30)
The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase
We describe the synthesis of a variety of lipophilic isosteres of nucleoside triphosphates as potential anti-HIV agents. The citrate molecule proved to be a good mimic of triphosphate by modelling in terms of charge and spatial distribution. Several lipophile derivatives of citrate were conjugated to the precedented anti-HIV nucleoside d4T via ester and amide linkages. A novel synthesis of 5'-amino-d4T is included. Intramolecular rearrangement of several amide-linked isosteres are also reported, along with an alternative synthetic strategy to the desired amide-linked isosteres.
Weaver, Richard,Gilbert, Ian H.
p. 5537 - 5562
(2007/10/03)
Solid-state esterification of codeine phosphate by the acid constituent of effervescent tablets
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Silver,Sundholm
p. 53 - 55
(2007/10/02)
A FACILE PREPARATION OF ASYM-MONOMETHYL, SYM-MONOMETHYL AND ASYM-DIMETHYL CITRATE
Asym-monomethyl citrate was prepared by hydrolysis of sym-dimethyl citrate.Sym-monomethyl and sym-dimethyl citrate were prepared by a selective hydrolysis of trimethyl citrate.