Palladium-catalyzed cross-coupling reaction of sulfoxonium ylides and benzyl bromides by carbene migratory insertion
A palladium-catalyzed cross-coupling reaction of sulfoxonium ylides and benzyl bromides has been developed, which has potential safety advantages over previous carbene coupling reactions using either diazo compounds or their in situ precursors. This reaction affords polysubstituted olefins, and features good substrate tolerance and is suitable for late-stage modification of biologically active molecules. Pd-carbene migratory insertion is supposed to be involved in this coupling reaction.
A chiral 6-membered n -heterocyclic carbene copper(I) complex that induces high stereoselectivity
A chiral 6-membered annulated N-heterocyclic (6-NHC) copper complex that catalyzes β-borylations with high yield and enantioselectivity was developed. The chiral 6-NHC copper complex is easy to prepare on the gram scale and is very active, showing 10000 turnovers at 0.01 mol % of catalyst without significant decrease of enantioselectivity and with useful reaction rates.
Park, Jin Kyoon,Lackey, Hershel H.,Rexford, Matthew D.,Kovnir, Kirill,Shatruk, Michael,McQuade, D. Tyler
supporting information; experimental part
p. 5008 - 5011
(2010/12/25)
Preparation of new 2,3-diphenylpropenoic acid esters - Good yields even for the more hindered Z isomers
The potassium salt of E- and Z-2,3-diphenylpropenoic acids prepaxed in situ could be esterified efficiently in DMSO with the appropriate alkyl halides at room temperature. In this way 10 previously undescribed esters of these acids were synthesised and characterised. Excellent yields were observed for most of the E isomers and the more hindered Z esters were also obtained in good yields, far better than those obtained applying the classical acid-catalysed esterification reaction.
Boros, Laszlo,Felfoeldi, Karoly,Palinko, Istvan
p. 256 - 263
(2007/10/03)
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