- Phosphoric Amides. Part 8. The Effect of the Ethyleneimine Substituent on the Solvolytic Reactivity of Phosphate and Phosphoramidate Bonds
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Rates and products of the base-catalysed hydrolysis of some amidoesters of phosphoric acid have been determined in the N,N-dimethyl derivative, the P-N bond is resistant, and the P-O bond deactivated towards hydrolysis, while in the N-methyl substrate, the reactivity of the ester link is similar to that in trimethyl phosphate.In the N-ethylene compound, both P-O and P-N bonds are strongly activated.The N-(β-chloroethyl) substrate reacts via fast, base-catalysed cyclization to the N-ethylene amidate.
- Davidowitz, Bette,Modro, Tomasz A.
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p. 303 - 306
(2007/10/02)
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