Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is
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Paragraph 0138
(2015/12/18)
SYNTHESIS OF 3-HYDROXYSPERMIDINE: AN UNUSUAL POLYAMINE CONSTITUENT OF CYTOTOXIC MARINE COMPOUNDS
A short, convergent synthesis of the title compound, (+/-)-N1-(3-aminopropyl)-1,4-diamino-2-butanol 6, was accomplished in 42percent overall yield by means of a highly regioselective 1,3-dipolar nitrone cycloaddition.
Ponasik, James A.,Ganem, Bruce
p. 9109 - 9112
(2007/10/02)
S-2,ω-diaminoalkyl dihydrogen phosphorothioates as antiradiation agents