Efficient synthesis of conformationally constrained, amino- triazoloazepinone-containing di- and tripeptides via a one-pot Ugi-Huisgen tandem reaction
Herein we describe a catalyst-free procedure employing an Ugi-4CR between a β-azido-α-amino acid, propargylamine, an isocyanide and an aldehyde, followed by a thermal azide-alkyne Huisgen cycloaddition to generate a 16-member library of amino-triazoloazepinone-bearing di- and tripeptides with up to four points of diversification and high atom economy. This journal is the Partner Organisations 2014.
Barlow,Jida,Tourwe,Ballet
p. 6986 - 6989
(2014/10/15)
Synthesis of γ-Lactam-Constrained Tryptophyllysine Derivatives
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Freidinger, Roger M.
p. 3631 - 3633
(2007/10/02)
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