Unexpected Reaction Pathways Leading to Thiodiglycol during the Degradation of Long-Chain Sulfur Mustards
Degradation of long-chain sulfur mustards with various commercial decontaminants unexpectedly forms thiodiglycol (TDG) through unreported reaction pathways. Chemical warfare agents (CWAs) degradation products have to be unambiguously related to their reference compounds in order to fulfill international verification protocols. Thus, the formation of TDG using water-based decontaminants introduces an uncertainty in the origin of this chemical that has been systematically used to unambiguously demonstrate the presence of yperite in environmental and biomedical samples. Therefore, these novel and unprecedented degradation pathways will result either in modifications of the international verification protocols for forensic purposes or in the exclusion of TDG as an exclusive marker of yperite.
Gómez-Caballero, Esther,Martínez-álvarez, Roberto,Sierra, Miguel A.
p. 12432 - 12439
(2018/10/15)
Facile one-step synthesis of dithiaalkanediols
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Kaushik, Mahabir P.,Rana, Hemlata
p. 268 - 272
(2007/10/03)
Hydrolysis and oxidation products of the chemical warfare agents 1,2-Bis[(2-chloroethyl)thio]ethane Q and 2,2′-Bis(2-chloroethylthio) diethyl ether T
Syntheses of diols of structure [HOCH2CH2S] 2(CH2)n in 86-95% yield from the sodium salt of 2-mercaptoethanol and Br(CH2)nBr (n = 1 to 5) or in 60-90% yield from 2-chloroethanol and NaS(CH2)nSNa (n = 2 to 5) are described. The diol [HOCH2CH2SCH 2CH2]2O was prepared in 82% yield from the sodium salt of 2-mercaptoethanol and [ClCH2CH2] 2O, and in 88% yield from 2-chloroethanol and [HSCH 2CH2]2O. Mono- and bis-sulfoxides and bis-sulfones of these species were prepared in generally high yield by treatment with an equivalent of KIO4 in aqueous methanol, two equivalents of NaIO4 in aqueous methanol, or four equivalents of H2O2 in trifluoroacetic acid respectively. The compounds are important analytical standards for investigating the fate of the chemical warfare agents sesquimustard Q and oxygen mustard T in environmental samples.
Timperley, Christopher M.,Black, Robin M.,Bird, Michael,Holden, Ian,Mundy, Joanna L.,Read, Robert W.
p. 2027 - 2046
(2007/10/03)
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