- Synthesis method of N-(4-fluorophenyl)-2-hydroxy-N-isopropylacetamide
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The invention belongs to the technical field of medical intermediates, and particularly relates to a synthesis method of N-(4-fluorophenyl)-2-hydroxy-N-isopropylacetamide. The N-(4-fluorophenyl)-2-hydroxy-N-isopropylacetamide is obtained by taking A as a
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- Synthetic method N - (4 - fluoroaniline) -2 - hydroxyl - N - isopropyl acetamide
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The invention belongs to the technical field of medical intermediates, and particularly relates to a synthesis method N - (4 - fluoroaniline) -2 - hydroxyl - N - isopropylacetamide. To the invention, fluoronitrobenzene is used as a starting material, and hydrogenation is carried out. Condensation gives compound A, compound A is coupled to compound B by amide coupling, compound B is subjected to nucleophilic substitution reaction to give compound C, compound C is exchanged through ester exchange to obtain N - (4 - fluoroaniline) -2 - hydroxyl - N - isopropyl acetamide. The synthesis route of the complete N - (4 - fluoroaniline) -2 - hydroxyl - N - isopropyl acetamide is provided, and the synthesized N - (4 - fluoroaniline) -2 - hydroxyl - N - isopropyl acetamide is high in yield and high in purity.
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- Flufenacet preparation method
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The invention discloses a flufenacet preparation method, which comprises synthesis of 2-methylsulfonyl-5-trifluoromethyl-1,3,4-thiadiazole, synthesis of 2-hydroxy-N-(4-fluoroaniline)-N-(1-methylethyl)acetamide and synthesis of 4'-fluoro-N-isopropyl-2-[5-(trifluridine)-1,3,4-thiadiazole-2-imide]acetamide. The optimal flufenacet preparation method is screened by a large number of experiments, the whole process is reasonable in design, particularly the steps of screening optimal reaction conditions and the optimal amount ratio, reaction temperature, reaction time and the like of reaction raw materials, the reaction yield (capable of reaching 90 percent or more) can be greatly increased, side reaction can be reduced, the reaction rate can be increased, the reaction raw materials can be recycled, the production cost is greatly reduced, and a broad application prospect is achieved.
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- Synthesis and herbicidal activity of N-aryl-2-heteroaryloxy-N-isopropyl acetamide
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A series of novel N-aryl-2-heteroaryloxy-N-isoproylacetamide derivatives were synthesized by multi-step reactions. Their structures were characterized by 1H NMR, MS and elemental analyses. The target compounds were evaluated for their herbicidal activities against Echinochloa crusgalli, Digitaria sanguinalis Scop., Abutilon theophrasti, Setaria viridis, Zinnia elegans and Acalypha australis. The results indicated that some of the title compounds displayed excellent herbicidal activities.
- Ye, Qing,Zhu, Xiao-Bo,Gu, Kai,Ni, Xiao-Quan,Gao, Jian-Rong,Wei-Rong, Miao
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p. 6931 - 6934
(2013/07/26)
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- Process for the preparation of hydroxycarboxanilides
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The present invention relates to a process for the preparation of hydroxycarboxanilides of the formula (1) STR1 in which R1 and R2 are identical or different and are hydrogen, halogen, a nitro group, a cyano group, a straight-chain o
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