Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide
One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.
Mete, Trimbak B.,Singh, Ankit,Bhat, Ramakrishna G.
supporting information
p. 4709 - 4712
(2017/11/21)
METHODS FOR THE PREPARATION OF TOPIROXOSTAT AND INTERMEDIATES THEREOF
The present invention relates to novel preparation methods for Topiroxostat through novel intermediates comprising novel methods for the formation of the triazole ring and for the cyanation of the pyridyl ring.
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Page/Page column 12
(2016/09/26)
Oxidative ammonolysis of 2,4,6-collidine at vanadium-titanium oxide catalyst
4-Cyanopyridine was synthesized from the readily obtainable 2,4,6-collidine by oxidative ammonolysis in the presence of vanadium-titanium oxide catalyst. Conditions under which the yield of the product amounted to 73% on the amount of the trimethylpyridin
Kagarlitsky,Krichevsky
p. 315 - 317
(2007/10/03)
A novel, selective free-radical carbamoylation of heteroaromatic bases by Ce(IV) oxidation of formamide, catalysed by N-hydroxyphthalimide
The Ce(IV)-NHPI system was used to generate a carbamoyl radical by oxidation of formamide; this nucleophilic radical has been successfully used in the carbamoylation of heteroaromatic bases.
Minisci, Francesco,Recupero, Francesco,Punta, Carlo,Gambarotti, Cristian,Antonietti, Fabrizio,Fontana, Francesca,Pedulli, Gian Franco
p. 2496 - 2497
(2007/10/03)
Process for the preparation of 2,4-pyridine dicarboxylic acid
A process for the preparation of carboxamides of nitrogen-containing aromatic heterocyclic compounds from the corresponding N-heterocyclic compounds by reaction thereof with formamide in the presence of peroxodisulfuric acid or a peroxodisulfate.
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(2008/06/13)
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