- Straightforward and mild deprotection methods of N-mono- and N1,N7-functionalised bisaminal cyclens
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Strategic removal of the bisaminal bridge of N-mono- and N1,N7-difunctionalised cyclen glyoxal derivatives was carried out via transamination processes with vicinal diamines. These procedures were found to be particularly well-suited for cyclen targets bearing sensitive groups.
- Oukhatar, Fatima,Beyler, Maryline,Tripier, Rapha?l
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p. 3857 - 3862
(2015/06/02)
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- A novel synthesis of 1,4,7,10-tetraazacyclododecane by the tandem reaction of a vinylsulfonium salt
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1,4,7,10-Tetraazacyclododecane was synthesized through 4 steps by using easily available diphenylsulfonium triflate as a key annulation reagent. The reaction condition was very mild and the yield was high. After oxidation and hydrolysis, 1,4,7,10-Tetraazacyclododecane, which had been proven to be the pivotal precursor for a wide range of MRI contrast reagents, was produced in an overall yield of 31%.
- Huang, Rui,Xie, Chunsong,Huang, Lin,Liu, Jinhua
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p. 195 - 198
(2013/07/26)
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- Preparation of hydroxyalkylpiperazinones by reacting an alkylene oxide with decahydropyrazino[2,3-b]pyrazine or its substituted derivatives
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The 4-(2-hydroxyalkyl)-2-piperazinones and their substituted derivatives are prepared by reacting a decahydropyrazino[2,3-b]pyrazine or its substituted derivative having at least one active amine hydrogen, with an alkylene oxide having 2 to 4 carbon atoms.
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- Trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin
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The chemical compound, trans-1,4,5,8-tetranitro-1,4,5,8-tetraazadecalin (D), is produced by the reaction of trans-1,4,5,8-tetraazadecalin with sodium nitrite and hydrochloric acid to obtain trans-1,4,5,8-tetranitroso-1,4,5,8-tetraazadecalin, followed by nitration to yield TNAD, useful as an explosive.
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