- Novel synthesis technology of tetronic acid
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The invention provides a novel synthesis technology of tetronic acid. According to the technology, cheap glycollic acid ester easy to obtain is adopted as an initial precursor and reacts with acetyl halides, a key intermediate 2-acetoxyl acetate is obtained, then, dickman condensation is perfomed on the alkaline condition, and the target product tetronic acid is obtained. The raw materials are easy to obtain, reaction conditions are mild, operation is easy and convenient, the synthesis cost is low, and large-scale industrial production is convenient. The final product tetronic acid is high in purity and yield, and the yield can reach 93% or above.
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Paragraph 0012; 0013
(2017/01/02)
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- A method for synthesizing tetranoic acid
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The invention discloses a synthetic method of tetronic acid. The synthetic method comprises the following steps: firstly oxidizing low-price easily-available natural sodium D-isoascorbate as a raw material through hydrogen peroxide, and acidifying through hydrochloric acid to prepare a key synthetic intermediate, namely erythronolactone; secondly, reacting erythronolactone with sulfonyl chloride to generate crude tetronic acid; finally, simply re-crystallizing obtained crude tetronic acid to obtain pure tetronic acid. The synthetic method has the characteristics of few synthetic steps, simple and convenient process, low synthetic cost, convenience for large-scale industrialized production and the like; finally obtained pure tetronic acid is high in yield and purity, the yield can reach more than 87%, and the purity can reach more than 99%.
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Paragraph 0041-0049
(2017/03/08)
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- Unexpected facile synthesis of tetronic acid during the research on stereospecific total synthesis of (+)-biotin starting from D-erythorbic acid as chiral pool
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The reaction of D-erythronolactone (8) with the methanesulfonyl chloride in the presence of triethylamine afforded, after unexpected elimination reaction, the tetronic acid is obtained in excellent yield and chemical purity, instead of the dimesylates (7)
- Li, Xiao-Kang,Xiong, Fei,Shen, Zhong-Yuan,Zhang, Shu-Ping,Zhou, Yi-Hao,Xu, Ming-Lu,Zhou, Zi-Qian
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p. 1957 - 1958
(2015/03/30)
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- Process for the Preparation of Tetronic Acid
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Tetronic acid of following Formula (2): is industrially efficiently prepared through a reaction of 4-hydroxy- or 4-alkoxy-acetoacetic acid or an ester thereof of following Formula (1): wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group, by carrying out the reaction in the presence of an organic solvent and an acid but substantially in the absence of water. Product tetronic acid is useful as an intermediate for fine chemicals such as pharmaceuticals, agricultural chemicals, and semiconductor resist polymers.
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Page/Page column 6
(2010/04/24)
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- Substitution and Michael Reactions of Bicyclic Tetronic, Tetramic and Thiotetronic Esters
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The 1,4-addition of several heteroatom and carbon nucleophiles to the bicyclic structures 1, 2, 3, and 13 are reported along with the conversion of the resultant adducts to substituted tetronic, tetramic, thiotetronic acids and butenolides; a novel reaction mechanism has been observed for the iodotrimethylsilane (TMSI) or acetic anhydride/magnesium bromide-mediated furan ring-opening reactions of the bicyclic tetronate 1.
- Bertucco, Alberto,Brennan, J.,Fachini, Marco,Kluge, Sabine,Murphy, Patrick J.,et al.
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p. 1831 - 1834
(2007/10/02)
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- A LABORATORY SYNTHESIS OF 4-HYDROXY-2-(5H)-FURANONE (β-TETRONIC ACID)
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A "one pot"-fashioned preparation of 4-hydroxy-2(5H)-furanone (β-tetronic acid) was conducted in 30-40percent overall yield starting from ethyl acetoacetate.
- Momose, Takefumi,Toyooka, Naoki,Takeuchi, Yumi
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p. 1429 - 1431
(2007/10/02)
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