- Micromide and Guamamide: Cytotoxic Alkaloids from a Species of the Marine Cyanobacterium Symploca
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Two new cytotoxins have been isolated from a species of marine cyanobacterium belonging to the genus Symploca that was collected in Guam. These new compounds, micromide (1) and guamamide (2), were accompanied by the known lipopeptides apramides A (3), B (4), and G (5). The planar structures of both alkaloids were elucidated by standard 2D NMR techniques, and the configurations of the amino acid-derived units in 1 were determined by chiral HPLC. The stereochemistry of the β-methoxyhexanoic acid in I was determined by derivatization with methyl D-mandelate, after acid hydrolysis, and comparison with synthetic standards.
- Williams, Philip G.,Yoshida, Wesley Y.,Moore, Richard E.,Paul, Valerie J.
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