cas 54143-55-4, Flecainide | Articles data

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Novel process for the preparation of flecainide, its pharmaceutically acceptable salts and important intermediates thereof
Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof that involves the use of the 2-halobenzoic acid and its derivatives as a starting material. The use of this process also allows for the synthesis of a novel intermediate useful in the production of Flecainide. This new process is an inexpensive and efficient process for the manufacture of these compounds.
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Page/Page column 4-5

(2010/02/11)

Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)-benzamide (FLECAINIDE)
Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.
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(2008/06/13)

Process for the preparation of 2,5-bis-(2,2,2-trifluoroethoxy)-n-(2-piperidyl-methyl)-benzamide (flecanide)
Process for the synthesis of FLECAINIDE comprising the reaction between 2,5-dihydroxybenzoic acid with trifluoroethanol perfluorobutanesulphonate to give the intermediate trifluoroethanol 2,5-bis-trifluoroethoxybenzoate, the reaction of said intermediate with 2-aminomethylpiperidine to give FLECAINIDE.
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(2008/06/13)

Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides
Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a substituted benzamido group, and their pharmaceutically acceptable salts, are found to be active as antiarrhythmic agents.
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(2008/06/13)

Chemical Properties

Appearance/Colour :White crystalline powder
Melting Point: 105-107 °C
Boiling Point: 434.9 °C at 760 mmHg
Flash Point:216.8 °C
Density: 1.286 g/cm³
Solubility:Chloroform (Slightly), Methanol (Slightly)
Storage Temp.:Refrigerator
PKA: pKa 9.3 (Uncertain)
PSA: 59.59000
LogP: 4.16040

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Chemical Properties

Appearance/Colour :White crystalline powder

Melting Point: 105-107 °C

Boiling Point: 434.9 °C at 760 mmHg

Flash Point:216.8 °C

Density: 1.286 g/cm³

Solubility:Chloroform (Slightly), Methanol (Slightly)

Storage Temp.:Refrigerator

PKA: pKa 9.3 (Uncertain)

PSA: 59.59000

LogP: 4.16040

Global suppliers and manufacturers of 54143-55-4total 81 suppliers on LookChem

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54143-55-4

Articles about 54143-55-4Total 4 be found

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Chemical Properties

Appearance/Colour :White crystalline powder

Melting Point: 105-107 °C

Boiling Point: 434.9 °C at 760 mmHg

Flash Point:216.8 °C

Density: 1.286 g/cm3

Solubility:Chloroform (Slightly), Methanol (Slightly)

Storage Temp.:Refrigerator

PKA: pKa 9.3 (Uncertain)

PSA: 59.59000

LogP: 4.16040

Global suppliers and manufacturers of 54143-55-4total 81 suppliers on LookChem

Density: 1.286 g/cm³