- Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides
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A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C?C bond cleavage of readily available alkyl aldehydes. Green and abundant molecular oxygen (O2) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcohols and α-ketoamides from aldehydes.
- Li, Tingting,Hammond, Gerald B.,Xu, Bo
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supporting information
p. 9737 - 9741
(2021/05/31)
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- GUANIDINE DERIVATIVES AS TRPC MODULATORS
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The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))
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- Visible-light photocatalytic reduction of sulfonium salts as a source of aryl radicals
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Triarylsulfonium salts are prompted to undergo efficient homolytic reduction by single electron transfer under mild photocatalytic conditions. The liberated aryl radical can then participate in carbon-carbon bond formation processes with allyl sulfones and activated olefins. Triarylsulfonium salts emerge as a valuable and alternative source of aryl radicals for synthesis. Copyright
- Donck, Simon,Baroudi, Abdulkader,Fensterbank, Louis,Goddard, Jean-Philippe,Ollivier, Cyril
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p. 1477 - 1482
(2013/06/27)
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- New, practical and effective sources of fluoride ion for desilylation to form carbon anions
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Suspensions of powdered glassy solids prepared by fusion of 1:1 mixtures of CsF-CsOH and CsF-CsCl effectively catalyze the generation of enolates, acetylide and other anions from trimethylsilylated precursors.
- Busch-Petersen, Jakob,Bo, Yunxin,Corey
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p. 2065 - 2068
(2007/10/03)
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- Photochemical Reaction of Ethyl 3-Oxo-2,4-diphenylbutanoate
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Irradiation of ethyl 3-oxo-2,4-diphenylbutanoate in hexane gave the products formed by recombination of the radicals (Ph-CH2 and/or Ph-CH-CO2Et)resulting from decarbonylation, together with small amounts of 1,2-diphenylethanol and ethyl α-hydroxyphenylacetate, whereas in benzene no 1,2-diphenylethanol was found.Under oxygen an increased amount of ethyl α-hydroxyphenylacetate and no radical recombination products were observed.
- Yoshioka, Michikazu,Osawa, Haruhiko,Fukuzawa, Shinji
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p. 877 - 879
(2007/10/02)
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