- Synthesis of cyclopropane-containing building blocks via Ir-catalyzed enantioselective allylic substitution reaction
-
Chiral cyclopropane-containing building blocks, which are very important synthetic intermediates for natural products or pharmaceuticals, were easily synthesized via Ir-catalyzed enantioselective allylic substitution reaction.
- Xia, Jibao,Zhuo, Chunxiang,You, Shuli
-
-
Read Online
- Ir-Catalyzed Enantioconvergent Synthesis of Diversely Protected Allenylic Amines Employing Ammonia Surrogates
-
The first iridium catalyzed, enantioconvergent amination of allenylic carbonates is reported. This process utilizes various commercially available carbamates and sulfonamides to generate allenylic amines including commonly employed protected groups (Boc, Fmoc, Cbz, Ts, Ns) in 62–82 % yield and 87–98 % ee. The products generated through this scalable procedure serve as effective linchpins for the rapid, enantiospecific synthesis of a wide range of complex structures.
- Carreira, Erick M.,Glatz, Fabian,Petrone, David A.
-
supporting information
p. 16404 - 16408
(2020/07/27)
-
- Substituted Pyrrolidine Amides II
-
The invention relates to compounds according to general formula (I), which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
- -
-
Paragraph 0393-0395
(2019/07/03)
-
- SELECTIVE KINASE INHIBITORS
-
Provided are pyrimidine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.
- -
-
Paragraph 0531; 0532
(2013/06/06)
-
- CERTAIN 1-(D-CYCLOPROPYLGLYCINYL)-4-(PIPERIDIN-4-YL)PIPERAZINE COMPOUNDS AS INHIBITORS OF THE SERINE PROTEASE FACTOR XA
-
The compounds of formula (I) in which R represents a hydrogen atom or a fluorine atom, or a pharmaceutically acceptable salt thereof are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
- -
-
Page/Page column 10
(2008/06/13)
-