- IF5 affects the final stage of the Cl-F exchange fluorination in the synthesis of pentafluoro-λ6-sulfanyl-pyridines, pyrimidines and benzenes with electron-withdrawing substituents
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A difficult chlorine-fluorine (Cl-F) exchange fluorination reaction in the final stage of the preparation of pentafluoro-λ6-sulfanyl-(hetero)arenes having electron-withdrawing substituents has now been elucidated through the use of iodine pentafluoride. A major side-reaction of C-S bond cleavage was sufficiently inhibited by the potential interaction between F and I with a halogen bonding.
- Cui, Benqiang,Kosobokov, Mikhail,Matsuzaki, Kohei,Tokunaga, Etsuko,Shibata, Norio
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supporting information
p. 5997 - 6000
(2017/07/10)
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- N-Chloro-N-methoxybenzenesulfonamide: A Chlorinating Reagent
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A structurally simple and reactive chlorinating reagent, N-chloro-N-methoxybenzenesulfonamide, was conveniently and economically prepared in high yield. 1,3-Diketones, β-keto esters, benzoyl trifluoroacetones, phenols, anisoles, heteroarenes, and aromatic amines were successfully chlorinated, and the products were obtained in good to high yields.
- Pu, Xiaoqiu,Li, Qingwei,Lu, Zehai,Yang, Xianjin
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supporting information
p. 5937 - 5940
(2016/12/26)
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- CFBSA: a novel and practical chlorinating reagent
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A structurally simple, highly reactive chlorinating reagent, N-chloro-N-fluorobenzenesulfonylamine (CFBSA), was conveniently prepared from inexpensive Chloramine B in high yield. A wide range of substrates were chlorinated with it to obtain products in good to high yields and appropriate selectivity.
- Lu, Zehai,Li, Qingwei,Tang, Minghua,Jiang, Panpan,Zheng, Hao,Yang, Xianjin
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supporting information
p. 14852 - 14855
(2015/10/06)
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- HETEROAROMATIC AMIDES AS INHIBITOR OF FACTOR XA
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This application relates to heteroaromatic amides (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.
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- DIAZOTIZATION OF SOME AMINODIAZINE N-OXIDES
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Diazotization of a number of aminopyrazine and aminopyrimidine N-oxides affords intermediate diazonium compounds which can be converted to the corresponding bromo and chloro analogs in the presence of the appropriate halide ions.In some instances, electrophilic aromatic substitution takes place prior to the diazotization step.Nucleophilic halogenation accompanying deoxygenation occurs with 2-aminopyrimidine N-oxide in the same manner as described for some 3-amino-1,2,4-triazine 2-oxides.
- Jovanovic, Misa V.
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p. 2011 - 2018
(2007/10/02)
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