- 11,12-Secoprostaglandins
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This invention relates to 11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of hypertension, for the prevention of thrombus formation, in preventing gastric secretion, and as regulators of the immune response.
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- 8-Aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins
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This invention relates to 8-aza-9-oxo(and dioxo)-thia-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the prevention of thrombus formation, to induce growth hormone release, and as regulators of the immune response.
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- 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins and processes
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This invention relates to 9-thia-, 9-oxothia, and 9-dioxothia-11,12-seco-prostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful for the treatment of skin diseases such as psoriasis, for the prevention of Thrombus formation, in stimulating the production of growth hormone in intact animals, and as regulators of the immune response.
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- 11,12 Secoprostaglandins. 1. Acylhydroxyalkanoic acids and related compounds
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The synthesis is described of a series of acylhydroxyalkanoic acids which embody structural modifications of that class of secoprostaglandins which are formally derived from the natural substances by scission of the cyclopentane ring between carbon atoms
- Bicking,Robb,Smith,Cragoe Jr.
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- 11,12-Secoprostaglandins
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This invention relates to 8,10-diaza-9-oxo(and thioxo)-11,12-secoprostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, and for the prevention of thrombus formation.
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