- Preparation method of N - alkyl -4 -nitrophthalimide
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The invention discloses a preparation method of N - alkyl -4 -nitrophthalimide, which comprises the following steps of 1) mixing phthalic anhydride, alkyl aldehyde and inorganic amine, reacting under the action of hydrogen, cooling and crystallizing, and drying to obtain N -alkyl phthalimide. Step 2) The 1 alkylphthalimide obtained in step N -) is subjected to nitration reaction, and the product is purified and dried to obtain the N -alkyl -4 -nitrophthalimide. The alkyl aldehyde in step 1) is preferably an alkyl aldehyde of carbon 1 - 4. The preparation method has the advantages of wide raw material source, low price, simple process, easiness in large-scale production and the like. Through one-step synthesis, the reaction efficiency is high, the device is simple and easy to operate, and green and environment-friendly.
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Paragraph 0049; 0051
(2021/10/27)
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- Black disperse dye composition having high color fastness to washing without the effects of metamerism
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The present invention provides a black disperse dye composition which comprises a blue disperse dye represented by chemical formula 1 or chemical formula 2, a yellow disperse dye, and a red disperse dye, and which has high fastness to washing without meta
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Paragraph 0053
(2020/10/10)
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- Method of constructing alpha-glucosidase inhibitor in three steps by taking imine as initial raw material
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The invention relates to a method of constructing an alpha-glucosidase inhibitor in three steps by taking imine as an initial raw material. By taking (E)-N-butyl-1-(4-nitryl phenyl) methylenimine as areaction raw material, the alpha-glucosidase inhibitor is synthesized successfully through three reaction steps: carbonylation reaction, reduction reaction and sulfonation reaction. The method has the characteristics of being novel in synthetic means, simple to operate, excellent in yield and the like.
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Paragraph 0023-0050
(2019/03/08)
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- A process for preparing N - alkyl -4 - nitro phthalimide method (by machine translation)
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The invention belongs to the field of organic synthesis technology, and relates to a N - alkyl phthalimide as raw materials, nitric acid as nitrating agent, through the continuous flow at low temperature the nitration reaction preparation N - alkyl - 4 - nitro phthalic acid imide series products. The reaction time is short, the production cycle is short, intermittent reaction kettle solves the problem caused by the accumulation of the raw materials, the reaction process is more stable, significantly improves the reaction efficiency. The different structure of the micro-channel in the reactor to enhance the mass transfer, heat transfer performance, keep the reaction temperature constant, to avoid the phenomenon of the rack frame, to reduce by-product, at the same time improves the safety of the reaction process. The micro-channel of the mass transfer effect of strong in the reactor, so that the liquid - liquid reaction liquid to be fully mixed, in the reaction process, concentrated sulfuric acid, can greatly reduce the consumption of nitric acid, reduces the production of waste. (by machine translation)
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Paragraph 0052; 0053; 0054; 0067; 0068; 0069
(2019/02/19)
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- Carbonylation Access to Phthalimides Using Self-Sufficient Directing Group and Nucleophile
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Herein we report a novel palladium-catalyzed oxidative carbonylation reaction for the synthesis of phthalimides with high atom- and step-economy. In our strategy, the imine and H2O, which are generated in situ from the condensation of aldehyde and amine, serve as self-sufficient directing group and nucleophile, respectively. This method provides rapid access to phthalimides starting from readily available materials in a one-pot manner. Various phthalimide derivatives are constructed efficiently, including medicinally and biologically active phthalimide-containing compounds.
- Ji, Fanghua,Li, Jianxiao,Li, Xianwei,Guo, Wei,Wu, Wanqing,Jiang, Huanfeng
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p. 104 - 112
(2018/02/19)
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- Method for one-pot synthesis of alpha-glucosidase inhibitor by carbonylation reaction
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The invention relates to a method for one-pot synthesis of an alpha-glucosidase inhibitor by carbonylation reaction. The method employs 4-nitrobenzaldehyde and n-butylamine as the reaction raw materials to carry out amine-aldehyde condensation, oxidative carbonylation reaction, nitro group reduction and sulfonation reaction so as to successfully synthesize the alpha-glucosidase inhibitor. The method has novel synthesis means, successfully synthesizes the alpha-glucosidase inhibitor by carbonylation reaction, and has the advantages of simple and easily available reaction raw materials, mild reaction conditions, and good atom economy and step economy of reaction, thus according with the development requirements of green chemistry.
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Paragraph 0030; 0031; 0032
(2017/10/10)
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- Azo-functionalized dendrimers
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We report the synthesis of azo-functionalized Starburst polyamidoamine (PAMAM) dendrimers. The following three systems of azo-functionalized PAMAM dendrimers were prepared by different synthetic routes: (i) phenylazo derivatives; (ii) naphthalimide azo derivatives; and (iii) phthalimide azo derivatives. Model compounds in each system were synthesized for spectroscopic comparison. Confirmation of structure was achieved using a combination of NMR and IR spectroscopy to ascertain the functional sites (i.e., the azo and the cyclic imides), while mass spectrometry and UV-vis spectrophotometry were employed to ascertain the extent of functionalization. Substitution by the azo pendent groups increased the thermal stability of PAMAM dendrimers (TGA weight loss of the naphthalimide azo-functionalized PAMAM dendrimers up to 300°C, ca. 5%).
- Cheon, Kap-Soo,Kazmaier, Peter M.,Keum, Sam-Rok,Park, Kuk-Tae,Buncel, Erwin
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p. 551 - 566
(2007/10/03)
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- Glucagon antagonists/inverse agonists
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Disclosed is a novel class of compounds of formula (I) wherein V, A, Y, Z, R1, E, X and D are as defined in the specification. These compounds act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor, the compounds are suitable for treating or preventing glucagon-mediated conditions and diseases such as hyperglycemia, Type 1 diabetes, Type 2 diabetes and obesity.
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