cas 54408-50-3, 5-Aminoquinaldine | Articles data ｜lookchem

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54408-50-3

Articles about 54408-50-3Total 6 be found

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Substitution effect on the one- and two-photon sensitivity of DMAQ "caging" groups
The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.
Petit, Morgane,Tran, Christine,Roger, Thomas,Gallavardin, Thibault,Dhimane, Hamid,Palma-Cerda, Francisco,Blanchard-Desce, Mireille,Acher, Francine C.,Ogden, David,Dalko, Peter I.
supporting information
p. 6366 - 6369
(2013/02/23)

5-SUBSTITUTED QUINOLINE AND ISOQUINOLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTIPHLOGISTICS
The invention relates to compounds of general formulas (IIa) or (IIb) and to their use as medicaments.
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Page/Page column 28

(2008/06/13)

Syntheses of Novel Quinolone-Chemotherapeutics, I: Pyridoquinolines and Pyridophenanthrolines as Derivatives of "lin-benzo-Nalidixic Acid"
Expansion of nalidixic acid (NA) has been accomplished by linear insertion of a benzo-ring between the two pyrido moieties.The resulting compounds exhibit antibacterial activity comparable to NA and are highly fluorescent.The regioselective hydrogenation of 1,7-phenanthrolines was studied. - Keywords: lin-Benzo-analogs; Quinolones; Pyridoquinoline; Pyridophenanthroline; Pyridophenanthroline; Regioselective hydrogenation of phenanthrolines; Fluorescence
Jordis, U.,Sauter, F.,Rudolf, M.,Cai, Gan
p. 761 - 780
(2007/10/02)

Preparation and analgesic activity of some tetrahydroquinolines and tetrahydroisoquinolines
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Ferranti,Garuti,Giovanninetti,Gaggi,Roncada,Nardi
p. 237 - 249
(2007/10/02)

Intramolecular cyclization of alkylhydroxylamines in acids
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Kawase,Kikugawa
p. 1615 - 1623
(2007/10/02)

Synthesis and antitumor properties of bis (quinaldine) derivatives
A series of 7-nitro. and amino-N,N'-bis(4-quinaldinyl)-αω-diaminoalkanes related to the 6-amino derivative was synthezied and tested in the mouse P-388 lymphocytic leukemia screen. Three of the 7-nitro derivatives were found to have moderate activity (T/C 140-150%), while other nitro derivatives were devoid of any antitumor properties. All five 7-amino compounds were moderately to strongly active (T/C 134-196%). In addition, binding of amino derivatives 2-6 to DNA was examined by their ability to (1) stabilize DNA to thermal denaturation and (2) inhibit the DNA-dependent RNA polymerase reaction in vitro. T(m) data suggest that these compounds bind to DNA and are strong inhibitors of the polymerase reaction (I50 = 6-9 X 10-6 M).
Sinha,Philen,Sato,Cysyk
p. 1528 - 1531
(2007/10/04)

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Chemical Properties

Appearance/Colour :Yellow or green crystals
Melting Point: 117-118 °C
Boiling Point: 316.6 °C at 760 mmHg
Flash Point:171.1 °C
Density: 1.169 g/cm³
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
Vapor Pressure: 0.000405mmHg at 25°C
Refractive Index: 1.681
PKA: 6.39±0.50(Predicted)
PSA: 38.91000
LogP: 2.70660

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