- DPPE: A convenient replacement for triphenylphosphine in the Staudinger and Mitsunobu reactions
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DPPE has been shown to replace triphenylphosphine in the Staudinger and Mitsunobu reactions. The resulting bis(phosphine oxide) by-product is readily removed allowing for rapid and simple purification of the reaction mixture.
- O'Neil, Ian A.,Thompson, Stephen,Murray, Clare L.,Kalindjian, S. Barret
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p. 7787 - 7790
(2007/10/03)
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- Tumor inhibiting saccharide conjugates
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The invention relates to a method for the preparation of glycoconjugates of phosphorus amides with the general formula STR1 where the connection of the sugar with the phosphoric acid amide mustard residue, and the ifosfamide mustard residue, respectively, occurs preferably in the 1-position, and where R1 and R2 ; which can be the same or different, denote hydrogen, lower C1 -C4 alkyl or C1 -C6 haloalkyl and where as sugar there can be present mono-, di-, or polysaccharides in all existing isomeric and enantiomeric forms, wherein in a known way protected brominated sugars are conjugated with the respective phosphorus compounds, and freed of the protective residues, and to the use of said compounds as anti-tumour drugs.
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- Synthesis of Chiral Spiroacetals from Carbohydrates
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Optically active spiroacetals are prepared from carbohydrates with an intramolecular hydrogen abstraction reaction as the key step.Both spiroacetal enantiomers are formally available from the same sugar.
- Martin, Angeles,Salazar, Jose A.,Suarez, Ernesto
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p. 4489 - 4492
(2007/10/02)
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