- Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity
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A new series of novel benzimidazole derivatives containing substituted pyrid-2-yl moiety and polyhydroxy sugar conjugated to the N-benzimidazole moiety has been synthesized and evaluated as orally bioavailable anti-inflammatory agents with anti-ulcerogenic activity. The anti-inflammatory and anti-ulcerogenic activities of these compounds were compared to diclofenac and omeprazole, respectively. In carrageenan-induced paw oedema assay, 2-methyl-N-((3,4-dimethoxypyridin-2-yl)methyl)-1H-benzimidazol-5-amine (12d) and 1-(1,2,3,5-tetrahydroxy-α-d-mannofuranose)-5-(((3,4-dimethoxypyridin-2yl) methyl)amino)-2-methyl-1H-benzimidazole (15d) displayed dose-dependent anti-inflammatory activities by decreasing the inflammation by 62% and 72%, respectively which is comparable to that of diclofenac (73%). In contrast to diclofenac, the anti-inflammatory activity of these compounds was not only free from any side effects on the gastric mucosa but also showed significant anti-ulcerogenic activity in rat pyloric ligation and ethanol-induced gastric ulcer models similar to that of omeprazole. Together, these findings suggest that 12d and 15d are potent anti-inflammatory agents with concurrent anti-ulcerogenic activity and support its clinical promise as a component of therapeutic strategies for inflammation, for which the gastric side effects are always a major limitation.
- El-Nezhawy, Ahmed O.H.,Biuomy, Ayman R.,Hassan, Fatma S.,Ismaiel, Ayman K.,Omar, Hany A.
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p. 1661 - 1670
(2013/05/09)
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- Double reductive amination and selective strecker reaction of a D-lyxaric aldehyde: Synthesis of diversely functionalized 3,4,5-trihydroxypiperidines
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A D-mannose-derived aldehyde with the D-lyxo configuration is a versatile key intermediate to functionally and stereochemically diversified piperidines. It allowed the synthesis of natural 3,4,5-trihydroxypiperidines and new analogs through a double reductive amination strategy and the synthesis of novel 2-cyanotrihydroxypiperidines through a highly regio-and diastereoselective Strecker reaction.
- Matassini, Camilla,Mirabella, Stefania,Goti, Andrea,Cardona, Francesca
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p. 3920 - 3924
(2012/09/08)
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- Chemoenzymatic synthesis of C8-modified sialic acids and related α2-3- and α2-6-linked sialosides
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Naturally occurring 8-O-methylated sialic acids, including 8-O-methyl-N-acetylneuraminic acid and 8-O-methyl-N-glycolylneuraminic acid, along with 8-O-methyl-2-keto-3-deoxy-d-glycero-d-galacto-nonulosonic acid (Kdn8Me) and 8-deoxy-Kdn were synthesized fro
- Yu, Hai,Cao, Hongzhi,Tiwari, Vinod Kumar,Li, Yanhong,Chen, Xi
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supporting information; experimental part
p. 5037 - 5040
(2011/10/09)
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- Stereoselective syntheses of polyhydroxylated azepane derivatives from sugar-based epoxyamides. Part 1: Synthesis from d-mannose
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An approach to the synthesis of polyhydroxyazepane derivatives from sugar-based epoxyamides or epoxyalcohols, in which the total regioselective epoxide opening by nitrogen nucleophiles is the key step, is described. Thus, novel polyhydroxyazepane carboxamides and aminomethyl polyhydroxyazepanes, with potential pharmacological interest, are synthesized from diacetone d-mannose. Configurational assignments of the obtained products were determined.
- Ona, Noe,Romero, Antonio,Assiego, Carmen,Bello, Claudia,Vogel, Pierre,Pino-Gonzalez, M. Soledad
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experimental part
p. 2092 - 2099
(2010/12/20)
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- An improved synthesis of a key intermediate for (+)-biotin from d-mannose
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An efficient and reproducible process for the synthesis of methyl 2,3,4,5-tetradeoxy-7,8-O-isopropylidene-d-arabino-nanonate (2), a key intermediate in the total synthesis of (+)-biotin (1), starting from readily available d-mannose is described. The cruc
- Chen, Fen-Er,Zhao, Jian-Feng,Xiong, Fang-Jun,Xie, Bin,Zhang, Ping
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p. 2461 - 2464
(2008/02/12)
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- Chemoenzymatic synthesis of [3,9-13C]-labeled NeuAc and KDN
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The chemoenzymatic synthesis of 13C-labeled sialic acid (NeuAc) and 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) as useful molecular probes for studying the conformation of sialyl or KDN oligosaccharides attached to proteins was perform
- Sato, Ken-Ichi,Akai, Shoji,Hiroshima, Toshiyuki,Aoki, Hidenori,Sakuma, Mayumi,Suzuki, Ken-Ju
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p. 3513 - 3516
(2007/10/03)
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- A new universal solid support for oligonucleotide synthesis
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Starting from 2,3:5,6-di-0-isopropylidene-α-D-mannofuranose, benzyl 5,6-ditrifluoroacetamido-5,6-dideoxy-2-0-(4,4'-dimethoxytrityl)-α-D-mannofuranose was prepared and attached to a controlled pore glass to generate a new universal solid support for oligon
- Azhayev, Alex V.
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p. 787 - 800
(2007/10/03)
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- A Synthetic Approach to the Squalestatins and Zaragozic Acids: Introduction of the C5 Stereocentre via an Ester-Enolate Claisen Rearrangement. The X-Ray Crystal Structure of an Intermediate
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In an overall plan to synthesize the anti-cholesterol agents the squalestatins and zaragozic acids, introduction of the C5 stereochemistry was achieved via an Ireland-Claisen rearrangement of the allyl ester (7) followed by methylation, which gives the es
- Gable, Robert W.,McVinish, Leasa M.,Rizzacasa, Mark A.
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p. 1537 - 1544
(2007/10/02)
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- Synthese von (+)-Aspicilin mit Bausteinen aus nachwachsenden Rohstoffen
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The 18-membered lichen macrolide (+)-aspicilin (1) is easily built up from compounds 14, 16, 3, and 24 following the C3 + C7 + C6 +C2 = C18 pattern (see Schemes).The synthesis requires 15 steps and gives 1 in 13percent overall yield from D-mannose (2).The
- Quinkert, Gerhard,Fernholz, Erhard,Eckes, Peter,Neumann, Doris,Duerner, Gerd
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p. 1753 - 1786
(2007/10/02)
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- Stereoselective Glycosylation of Alcohols and Silyl Ethers Using Glycosyl Fluorides and Boron Trifluoride Etherate
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The stereoselective glycosylation of alcohols and their silyl ethers has been achieved using O-alkyl-, O-acyl-, and acetal-protected glycosyl fluorides of the pyranose and furanose series and boron trifluoride etherate in CH2Cl2.
- Kunz, Horst,Sager, Wilfried
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p. 283 - 287
(2007/10/02)
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- SYNTHESIS OF 5-AMINO-5-DEOXY-D-MANNOPYRANOSE AND 1,5-DIDEOXY-1,5-IMINO-D-MANNITOL, AND INHIBITION OF α- AND β-D-MANNOSIDASES
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The title compounds and the corresponding L-gulo derivatives were synthesised in 6 steps from benzyl 2,3:5,6-di-O-isopropylidene-α-D-mannofuranoside.The Ki values, determined from inhibition studies with α-D-mannosidases from jack beans, almonds, and calf liver, and β-D-mannosidase from Aspergillus wentii, ranged from 70 to 400 μM for the mannitol derivative and from 1.2 to 20 μM for 5-amino-5-deoxy-D-mannopyranose, i.e., inhibition is E2-E4-fold stronger than with D-mannose.Marked enhancement of inhibition with increasing pH is ascribed to the ionisation of a carboxyl group at the active site, forming an ion pair with the protonated inhibitor.The inhibition equilibrium between the jack-bean enzyme and the mannose derivative was approached slowly with kapp 2.0E5 M-1.min-1.The mannose-derived inhibitor was also inhibitory against β-D-glucosidases from almonds and Asp. wentii, with Ki values only 20-150-times larger than those for the inhibition of these enzymes by 5-amino-5-deoxy-D-glucopyranose.This moderate discrimination in binding of D-gluco and D-manno derivatives is in marked contrast to the high specificity shown by the glucosidase in catalysing the hydrolysis of mannosidases.A similar low specificity with respect to binding, combined with highly specific catalysis, was also seen with the mannosidases acting on inhibitors and substrates with the D-gluco configuration.
- Legler, Guenter,Juelich, Elisabeth
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- A Simple Regioselective Partial Hydrolysis of Di-O-isopropylidene Monosaccharides with Copper(II) Ion
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Copper(II) ion was found to be effective for regioselective removal of the 5,6-O-isopropylidene group of α-D-mannose and α-D-glucose derivatives in alcohols at ambient temperature.
- Iwata, Masaaki,Ohrui, Hiroshi
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p. 2837 - 2838
(2007/10/02)
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