- 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS
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The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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Page/Page column 39
(2014/01/07)
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- ARYL VINYL SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF
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Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula (I): wherein Ar1, Ar2, D, G, formula (a), m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, synthetic processes, and intermediates useful in such processes are provided.
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Page/Page column 81
(2008/06/13)
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- HETEROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISEASE
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Heterocyclic compounds of the formula (I) are provided: wherein ring A, ring B, R1, R2, R3, R4, Y, m, n and q are as defined herein. R1 is in particular amidino. The invention further provides particular benzothiophene compounds. Compounds of the invention may be useful as inhibitors of Factor IXa and in the therapy of cardiovascular conditions and diseases, e.g. thrombosis.
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Page/Page column 231
(2008/06/13)
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- Thiocyanohydrins, a new class of compounds, precursors of unstabilized thiocarbonyl derivatives
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Mono- and dialkylated thiocyanohydrins are prepared by alkylation of the parent compound 2 (NCCH2SH) under mild conditions. Some examples of the reactivity of this new class of compounds are also given.
- Gaumont,Wazneh,Denis
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p. 4927 - 4940
(2007/10/02)
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