- Reductive α-substitution of sulfoxides with grignard reagents promoted by a magnesium amide
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The reactions of sulfoxides bearing α-hydrogen(s) (RSOCHR1R2: R-alkyl or aryl; R1, R2 = H, alkyl, or aryl) with Grignard reagents (R3MgBr: R3 = Et, Ph, or vinyl) in the presence of the diisopropylaminomagnesium reagent, generated in situ by the treatment of diisopropylamine with the appropriate Grignard reagents in diethyl ether, have resulted in the formation of the corresponding sulfides (RSCR1R2R3) in moderate to good isolated yields.
- Kobayashi, Kazuhiro,Yokota, Kouichi,Akamatsu, Hideki,Morikawa, Osamu,Konishi, Hisatoshi
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p. 441 - 443
(2007/10/03)
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- Alkylation with Oxalic Esters. Scope and Mechanism.
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Alkyl oxalates are well suited for use as standard synthetic reagents in N-, O-, or S-alkylations and often display an interesting regioselectivity.The mechanism seems to be a direct alkylation of the substrate anion.
- Bergman, Jan,Norrby, Per-Ola,Sand, Peter
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p. 6113 - 6124
(2007/10/02)
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