Ambident polyfluoroalkyl-substituted pyrazoles in the methylation reactions
The reactivity of polyfluoroalkyl-containing pyrazoles has been estimated using the quantum chemical calculations. A good regioselectivity in the methylation of polyfluoroalkylpyrazoles was reached while varying the reaction conditions. Under basic condit
Ivanova, Anna E.,Burgart, Yanina V.,Saloutin, Viktor I.,Slepukhin, Pavel A.,Borisevich, Sophia S.,Khursan, Sergey L.
Synthese des F-alkylpyrazoles: Identification par RMN de 19F et comparaison avec les homologues hydrocarbones
In this paper, we report the synthesis of forty new pyrazoles substituted by one or more perfluoroalkyl chains.These compounds were obtained by condensation of a hydrazine (substituted or not) on an F-alkyl β-diketone.Unlike hydrocarbon chemistry, a react