Novel carboxaldehyde mediated synthetic pathway for 5′-amino adenosine analogues
Modifications of the 5′-position of adenosine have been prepared via a novel 5′-carboxaldehyde synthon. The described methodology should prove useful for making related compounds in which amine-derived moieties off the 5′-position of adenosine (or related nucleoside congeners) can be easily incorporated via reductive amination, especially for the incorporation of aromatic amines.
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases
Conformationally restricted arginine analogues (1-5) were synthesized and found to be alternative substrates or inhibitors of the three isozymes of nitric oxide synthase (NOS). A comparison of k(cat)/K(m) values shows that (E)-3,4-didehydro-d,l-arginine (
Lee, Younghee,Marletta, Michael A.,Martasek, Pavel,Roman, Linda J.,Masters, Bettie Sue Siler,Silverman, Richard B.
p. 1097 - 1104
(2007/10/03)
α-amino-α-(ureidophenyl)acetamidocephalosporins
Cephalosporins with a α-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of α-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.
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(2008/06/13)
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