- Nucleophilic Organic Base DABCO-Mediated Chemospecific Meinwald Rearrangement of Terminal Epoxides into Methyl Ketones
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Nucleophilic organic base DABCO (1,4-diazabicyclo[2.2.2]octane)-mediated Meinwald rearrangement of various epoxides was investigated. 2-Aryl-, alkenyl-, and alkynylepoxides generate the corresponding methyl ketones chemospecifically in good to excellent yields. The current DABCO-mediated Meinwald rearrangement of epoxides features readily accessible starting materials, a wide substrate scope, a transition-metal- and acid-free environment, and chemospecificity in the isomerization of epoxides.
- Li, Siqi,Shi, Yi,Li, Pingfan,Xu, Jiaxi
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p. 4443 - 4450
(2019/04/30)
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- CuH-catalyzed enantioselective 1,2-reductions of α,β-unsaturated ketones
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The first study on a general technology for arriving at valued nonracemic allylic alcohols using asymmetric ligand-accelerated catalysis by copper hydride is described.
- Moser, Ralph,Boskovia, Zarko V.,Crowe, Christopher S.,Lipshutz, Bruce H.
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supporting information; experimental part
p. 7852 - 7853
(2010/08/04)
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- Organic Compounds
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Disclosed are compounds having the ability to inhibit cytochrome P450 2A6, 2A13, and/or 2B6 and tobacco products comprising them. Also disclosed are pharmaceutical compositions comprising them.
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Page/Page column 8-9
(2010/05/13)
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- ORGANIC COMPOUNDS
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Disclosed are compounds having the ability to modulate, namely to improve, enhance and or modify fragrance compositions due to their ability to inhibit cytochrome P450 enzymes, e.g. CYP2A13 and CYP2B6.
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Page/Page column 28-29
(2008/12/04)
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- Stereospecific synthesis of methyl vinyl ketones
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A stereospecific synthesis of enones 3 by coupling reaction of α-acetoxy alkyl methyl vinyl ketones 2 and Gilman or Grignard reagents in the presence of a catalytic amount of copper(I) salt at low temperature, is described.
- Chamakh,M'hirsi,Amri
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p. 1157 - 1163
(2007/10/03)
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