- The role of botrydienediol in the biodegradation of the sesquiterpenoid phytotoxin botrydial by Botrytis cinerea
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The biotransformation of botrydienediol (6) labelled with deuterium on carbons C-10 and C-15 has been studied. This has led to modification of some previous assumptions about the biodegradative route of botrydial. The [10-2H,15-2H]-botry-1(9)-4-diendiol (12) was transformed into dehydrobotrydienediol derivatives 13-15 but it was not incorporated into secobotryane skeleton (7). In addition, three new sesquiterpenoids have been isolated, which shed further light on the secondary metabolites of Botrytis cinerea. From the point of view of persistence of these toxins in the food chain, the easy biotransformation and different biodegradative routes of botrydial (1), seem to indicate that the toxin may not persist in the plant for a long time as it will be metabolized by the fungi and the plant.
- Daoubi, Mourad,Durán-Patrón, Rosa,Hernández-Galán, Rosario,Benharref, Ahmed,Hanson, James R.,Collado, Isidro G.
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Read Online
- Botrylactone: New interest in an old molecule - Review of its absolute configuration and related compounds
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The absolute configuration of botrylactone, a unique compound with an interesting polyketide lactone skeleton with two oxirane bridges previously isolated from Botrytis cinerea and described as a powerful antibiotic, has been reviewed on the basis of sign of the optical rotation, NOE experiments and NMR method. The isolation of 7-deoxybotrylactone and 5-hydroxy-7-(4-hydroxydec-2(3)- enoyl) botrylactone enables us to characterize an intriguing new family of compounds with this interesting polyketide skeleton. A common biosynthetic origin with botcinin derivatives is proposed. Copyright
- Moraga, Javier,Pinedo, Cristina,Durán-Patrón, Rosa,Collado, Isidro G.,Hernández-Galán, Rosario
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experimental part
p. 417 - 420
(2011/03/19)
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