- Levodopa methyl ester hydrochloride synthetic method
-
The invention relates to a synthesis method of L-dopa methyl ester hydrochloride, which comprises the following steps: by using veratone as a raw material, carrying out amidation to obtain 2-amino-3-(3,4-dimethoxyphenyl)propanamide, carrying out amide oxidation into carboxy group to obtain 2-amino-3-(3,4-dimethoxyphenyl)propionic acid, removing methoxy group to obtain 2-amino-3-(3,4-dihydroxyphenyl)propionic acid, and finally, carrying out methyl ester conversion and acidification to obtain the target product 2-amino-3-(3,4-dimethoxyphenyl)alanine methyl ester hydrochloric acid. The method has the advantages of accessible reaction raw materials, ingenious technique concept, simple steps and no use of virulent reagents, is simple to operate, conforms to the requirements for green chemical industry, and is suitable for industrial production.
- -
-
-
- Bio-inspired enantioselective full transamination using readily available cyclodextrin
-
The mimics of vitamin B6-dependent enzymes that catalyzed an enantioselective full transamination in the pure aqueous phase have been realized for the first time through the establishment of a new “pyridoxal 5′-phosphate (PLP) catalyzed non-covalent cyclodextrin (CD)-keto acid inclusion complexes” system, and various optically active amino acids have been obtained.
- Zhang, Shiqi,Li, Guangxun,Liu, Hongxin,Wang, Yingwei,Cao, Yuan,Zhao, Gang,Tang, Zhuo
-
p. 4203 - 4208
(2017/02/05)
-