- 2′,4′,6′-trihydroxy-1-methoxyacetophenone monohydrate at 150 K
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The geometry of the title compound, 2-methoxy-1-(2,4,6-trihydroxyphenyl)ethanone, C9H10O5·H2O, is determined by the presence of an intramolecular hydrogen bond; the geometry of the benzene ring is distorted by a
- Ferreira, Ester S. B.,Hulme, Alison N.,McNab, Hamish,Parsons, Simon,Quye, Anita
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- Preparation method of flavone compound intermediate
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The invention provides a preparation method of a flavone compound intermediate compound A. The intermediate compound obtained by the method of the invention has the advantages of few impurities, highyield and high product purity.
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Paragraph 0059-0063
(2019/10/01)
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- Myricitrin preparation method
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The invention belongs to the technical field of pharmaceutical chemical synthesis, in particular relates to a preparation method of the slots. The invention the equivalent preparation method is as follows: a, in order to 1 - 1 as shown in the compound as a raw material, with the methoxy second grade nitrile under acidic conditions in the acylation reaction to obtain 1 - 3 as shown in the; second, 1 - 3 is shown with the compound 3, 4, 5 - trimethoxy benzoic anhydride generating rearrangement reaction to 1 - 5 as shown in the; three, 1 - 5 shown BBr3 compound in the dichloromethane solution takes place in the demethylation reaction generating 3 - 1 compound of formula, is myricetin. The invention relates to a fully synthetic routes proceed from the phloroglucinol, by the three-step reaction, to 60% of the total yield has succeeded in synthesizing myricetin. With cheap raw material, mild reaction conditions, synthetic route is short, and the yield is high, the operation is simple, and little environmental pollution and the like.
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Paragraph 0028-0032
(2019/01/08)
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- SYNTHESIS OF POLYHYDROXY CHROMENONE COMPOUNDS AND THEIR ANTI-TUMOR EFFECTS
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The present invention is directed to chromenone compounds of formula (I), pharmaceutically acceptable salts, prodrugs thereof, and the composition comprising the compounds or the like. They can be used to modulating the function of estrogen receptor ER-α36 preventing and/or treating the estrogen related diseases, such as breast cancer, leukemia, liver cancer and etc.
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Paragraph 0081
(2015/02/18)
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- SYNTHESIS OF POLYHYDROXY BENZOPYRAN KETONE COMPOUND AND ANTI-TUMOR EFFECT THEREOF
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The present invention is directed to chromenone compounds of formula (I), pharmaceutically acceptable salts, prodrugs thereof, and the composition comprising the compounds or the like. They can be used to modulating the function of estrogen receptor ER-α36 preventing and/or treating the estrogen related diseases, such as breast cancer, leukemia, liver cancer and etc.
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Paragraph 0055
(2014/12/09)
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- BENZOPYRONE ESTROGEN RECEPTOR REGULATOR
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The present invention provides a kind of benzopyrone compounds having a structure of formula (I) and the pharmaceutically acceptable salts or prodrugs thereof, and the pharmaceutical compositions containing such compounds, which can be used to regulate the novel estrogen receptor ER-a36, and prevent and/or treat the related diseases mediated by the ER-a36 receptor, such as cancers, etc.
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Paragraph 0077
(2013/11/19)
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- BENZOPYRONE ESTROGEN RECEPTOR REGULATOR
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The present invention provides a kind of benzopyrone compounds having a structure of formula (I) and the pharmaceutically acceptable salts or prodrugs thereof, and the pharmaceutical compositions containing such compounds, which can be used to regulate the novel estrogen receptor ER-a36, and prevent and/or treat the related diseases mediated by the ER-a36 receptor, such as cancers, etc.
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Paragraph 0264
(2013/11/19)
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- CHROMEN-4-ONE DERIVATIVES AS SELF-TANNING SUBSTANCE
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The invention relates to the use of compounds of the formula (I), where R1 and R2 may be identical or different and stand for H, OH, OCH3, CH3, CH2OH or CH2OCH3, R3 stands for H or straight-chain or branched C1- to C20-alkyl groups, R4 stands for H or OR8, R5 and R6 may be identical or different and are selected from —H, —OH, straight-chain or branched C1 to C20-alkyl groups, straight-chain or branched C3- to C20-alkenyl groups, straight-chain or branched C1- to C20-hydroxyalkyl groups, where the hydroxyl group may be bonded to a primary or secondary carbon atom of the chain, and furthermore the allyl chain may also be interrupted by oxygen, and R8 stands for H or straight-chain or branched C1- to C20-alkyl groups, with the proviso that R2 does not denote H if R1 denotes CH3, as self-tanning agents, and to compounds and the preparation thereof.
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- Synthesis of kaempferitrin
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(Chemical Equation Presented) A short synthesis of Kaempferitrin (1), a 3,7-diglycosylflavone, is reported. Key features include the synthesis of a protected form of kaempferol in which all four hydroxy groups are differentiated and the first bis-glycosyl
- Urgaonkar, Sameer,Shaw, Jared T.
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p. 4582 - 4585
(2008/02/05)
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- Structure-activity requirements for flavone cytotoxicity and binding to tubulin
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A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy- 5,7,3'-trihydroxyflavone, 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resulting cytotoxicity profiles of these flavones were compared for deg
- Beutler, John A.,Hamel, Ernest,Vlietinck, Arnold J.,Haemers, Achiel,Rajan, Padinchare,Roitman, James N.,Cardellina II, John H.,Boyd, Michael R.
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p. 2333 - 2338
(2007/10/03)
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- An improved synthesis of the anti-picornavirus flavone 3-O-methylquercetin
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Two optimised procedures to synthesise 3-O-methylquercetin (1), an important antivirally active flavone, are presented: one is based on an Allan-Robinson condensation, the other one on a modified phase transfer catalysed Baker-Venkataraman transformation.
- Boers, Frank,Deng, Bo-Liang,Lemiere, Guy,Lepoivre, Jozef,De Groot, Alex,Dommisse, Roger,Vlietinck, Arnold J.
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p. 313 - 316
(2007/10/03)
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