- Regioselective alkylation of guanines using 2-acetoxytetrahydrofurans
-
Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyltetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This was used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclovir.
- Geen, Graham R.,Kincey, Peter M.,Spoors, P. Grant
-
p. 1781 - 1784
(2007/10/03)
-
- Synthesis of acyclic nucleoside derivatives
-
Methods and novel intermediates of the formula: wherein R6 and R7 are lower alkyl or benzyl or R6 and R7 taken together are —CH2CH2—, —CH2CH2CH2— or —CH2CH2CH2CH2CH2—, R8 is C1-C21 alkyl or a C2-C21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxy C1-C6 alkyl, C1-C6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a —C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.
- -
-
-
- A VERSATILE SYNTHON APPROACH TO THE PREPARATION OF SOME PPHOSPHOLIPASE A2 INHIBITORS
-
A versatile route for the preparation of 2-ketomethylene phospholipids using dithiane chemistry is described.
- Golec, J. M. C.,Hedgecock, C. J. R.,Kennewell, P. D.
-
p. 547 - 550
(2007/10/02)
-
- New 4-substituted 2-alkoxytetrahydrofuran derivatives
-
The present invention describes a process to obtain 4-substituted 2--alkoxytetrahydrofuran derivatives of formula I. wherein,-R1 represents an alkyl or phenylalkyl radical; -R2 is hydrogen, C1-C4-acyl or C1
- -
-
-
- 4-substituted-2-alkoxytetrahydrofuran derivatives
-
The present invention describes a process to obtain 4-substituted 2-alkoxytetrahydrofuran derivatives of formula I, STR1 wherein, --R1 represents an alkyl or phenylalkyl radical; --R2 is hydrogen, C1 -C4 -acryl
- -
-
-