- Copper-mediated aerobic oxidative cleavage of α,β-unsaturated ketones to 1,2-diketones
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The copper-mediated aerobic oxidative cleavage of α,β- unsaturated ketones to synthesize 1,2-diketones by using potassium acetate as a catalyst and sodium iodide as a promoter in acetic acid is described. The protocol has the advantages of using inexpensive and non-toxic raw materials, high yield and simple work-up procedure. the Partner Organisations 2014.
- Li, Zheng,Yin, Junjun,Wen, Gong,Li, Tianpeng,Shen, Xiaoli
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p. 32298 - 32302
(2014/08/18)
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- Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines
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The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet properties may be mediated by interference with the arachidonic acid pathway.
- Ramajayam,Giridhar, Rajani,Yadav,Balaraman,Djaballah, Hakim,Shum, David,Radu, Constantin
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p. 2004 - 2010
(2008/12/22)
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- Synthesis of novel substituted diaryl-1,4-diazepines
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In this paper a convenient route to new 2,3-diaryl-substituted 1,4-diazepines is described through cyclization of ethanedione derivatives and 1,3-propanediamine. The ethanedione derivatives required were synthesized by microwave-assisted oxidation from ethanones.
- Ramajayam,Giridhar, Rajani,Yadav
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p. 901 - 906
(2008/02/12)
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- An efficient and time saving microwave-assisted selenium dioxide oxidation of 1,2-diarylethanones
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Selenium dioxide oxidation of 1,2-diarylethanones to corresponding diones by conventional method takes upto 8 hr. The same oxidation under microwave radiations using dimethylsulfoxide as solvent reduces the reaction time considerably (30 to 90 sec). The method reported is efficient and time saving.
- Shirude,Patel,Giridhar,Yadav
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p. 1080 - 1085
(2007/10/03)
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- One-pot conversion of α-substituted arylacetaldehydes into α-dicarbonyl compounds
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α-dicarbonyl compounds 7-12 can be easily prepared by reaction of methylene chloride solutions of several α-substituted arylacetaldehydes 1-6 with a slight excess of tris-(o,p-dibromophenyl) ammoniumyl hexachloro antimonate A.
- Lopez, Luigi,Mele, Giuseppe,Nacci, Angelo,Troisi, Luigino
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p. 3897 - 3900
(2007/10/02)
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- REACTIONS OF NITRILE OXIDES WITH 2-LITHIO-1,3-DITHIANES, SYNTHESIS OF α-DIKETONES
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Nitril oxides (2) were treated with 2-lithio-1,3-dithianes (4) to give in good yields masked ketoximes (5), new synthetic tools for α-diketones.
- Yamamori, Teruo,Adachi, Ikuo
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p. 1747 - 1750
(2007/10/02)
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