Synthesis of novel strobilurin-pyrimidine derivatives and their antiproliferative activity against human cancer cell lines
A series of new strobilurin-pyrimidine analogs were designed and synthesized based on the structures of our previously discovered antiproliferative compounds I and II. Biological evaluation with two human cancer cell lines (A549 and HL60) showed that most of these compounds possessed moderate to potent antiproliferative activity. Two potent candidates (8f, IC50 = 2.2 nM and 11d, IC50 = 3.4 nM) were identified with nanomolar activity against leukemia cancer cell line HL60 for further development. This activity represents a 1000- to 2500-fold improvement compared to the parent compounds I and II and is 20- to 30-fold better than the chemotherapy drug, doxorubicin. The present work provides strong incentive for further development of these strobilurin-pyrimidine analogs as potential antitumor agents for the treatment of leukemia.
Some Diazinon Analogues Containing the 4-Trifluoromethyl Group
Diazinon analogues were prepared containing trifluoromethyl in place of the 4-methyl group and methylthio (2a), amino (2b), dimethylamino (2c), methylphenylamino (2d), or isopropyl (2e) in position 2 of the pyrimidine ring.The most active analogue (2b) wa
Gershon, Herman,Clarke, Donald D.,Grefig, Anthony T.,Anderson, Thomas E.
p. 289 - 292
(2007/10/02)
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