Direct synthesis of N-substituted, functionalized aspartic acids using alkali maleates and amines
A practical and general one-pot synthesis of mono-N-substituted, functionalized aspartic acids has been developed. The N-substituted aspartic acids are formed directly from alkali maleates and primary amines in hot DMSO. Products from several different primary amines can be prepared chemoselectively in moderate to good yields.
Piispanen, Peter S.,Pihko, Petri M.
p. 2751 - 2755
(2007/10/03)
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