- The reactivity of 1,1-diamino-2,2-dinitroethene (FOX-7)
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The reactivity of 1,1-diamino-2,2-dinitroethene (DADNE) or FOX-7 was studied. Various reactions like cycloadditions, nitration, halogenation and acylation were performed in order to evaluate the reactivity of the C-C double bond and the amino moieties. Se
- Hervé, Grégoire,Jacob, Guy,Latypov, Nikolaj
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- Quinoline and 2-nitroimino-1, 3-diazacycloalkane hybrids: Design, synthesis and insecticidal activity
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A library of new hybrid molecules comprising quinoline, 2-nitroimino-1, 3-diazacycloalkane motifs were designed and synthesized as plausible neonicotinoid analogues. These compounds were synthesized from 2-chloro/aryloxy-3-formyl quinolines and guanidine nitrate with the coupling of 2-chloro/aryloxy-3-(chloromethyl)quinolines, 2-nitroimino-1, 3-diazacycloalkanes under phase transfer catalysis (PTC) as crucial step. All the compounds were obtained in excellent yields (80–90%) and were characterized by 1H, 13C NMR and mass spectrometry. The newly generated compounds were screened for insecticidal activity against aphids in safflower field and some of them displayed moderate activity.
- Sowmya, Jonnalagadda,Padma, Banda,Leelavathi, Panaganti
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- Synthesis of nitro substituted compounds of industrial catalytic method
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The invention relates to a synthetic nitro substitution compound, in particular to an industrial catalysis method of nitroguanidine. A novel ternary catalytic system is formed by screening out different kinds of component combinations, the reaction environment with low concentration nitric acid is achieved by using an additive, the nitroguanidine is used as raw materials, and the preparation for the nitroguanidine can be finished by the reaction with high yield within a short time, so that the utilization of high level of acid which has strong corrosion resistance and high volatilization can be avoided and production cost is reduced. Through the optimization of process parameters, the optimal technology of the industrial catalysis of the nitroguanidine which is suitable for being produced widely is explored, the reaction yield and material utilization rate are improved greatly, and application prospects and market value are wide.
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Paragraph 0034
(2017/03/14)
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- PYRIMIDINONE COMPOUNDS FOR USE IN THE TREATMENT OF DISEASES OR CONDITIONS MEDIATED BY LP - PLA2
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The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema (I).
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Page/Page column 36
(2012/06/30)
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- PROCESS OF SEPARATING GUN PROPELLANT COMPONENTS AND USEFUL BYPRODUCTS THEREOF
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Methods for the separation of targeted components from gun propellant formulations. In particular, the methods separate targeted components in a usable/useful form. Preferred methods are directed to the separation of nitrocellulose, nitroguanidine and/or nitroglycerine from a formulation containing one or more of these components.
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- Synthesis and properties of thiamethoxam and related compounds
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The neonicotinoids are the most successful chemical class of insecticides reaching sales of more than $1 billion in 2003, mainly due to the excellent market performance of imidacloprid and thiamethoxam. This paper describes the discovery, the synthesis and the insecticidal activity of thiamethoxam and related compounds and reports the hydrolytic stability and the degradation pathways of thiamethoxam together with the synthesis of the degradation products.
- Maienfisch, Peter
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p. 353 - 359
(2007/10/03)
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- Synthesis and Some Properties of 1,2-Dinitroguanidine
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1,2-Dinitroguanidine is a product of nitroguanidine nitration with nitric acid and its mixtures with sulfuric acid and oleum. It is a diacid (pK a 1.11, ~11.5) and at the same time a weak base undergoing protonation at the nitrogen of the amino group (pKBH+ -5.81). The decomposition kinetics of 1,2-dinitroguanidine was studied by spectrophotometric method both in acid and alkaline media, and the mechanism of the process was assumed. In the media of high acidity (Ho > -8) the 1,2-dinitroguanidine suffers reversible denitration into nitroguanidine. At lower acidity its conjugate acid or molecular form undergoes hydrolysis yielding nitrourea. Monoanion of 1,2-dinitroguanidine in a weak acid or in an alkali is hydrolyzed into N,N′-dinitrourea. The reaction of 1,2-dinitroguanidine with alkali in alcohol provides its salts, with nitrogen-containing bases form both salts and derivatives of 2-nitroguanidine. The treatment of 1,2-dinitroguanidine with haloalkanes results in its N-alkylated products.
- Astrat'yev,Dashko,Kuznetsov
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p. 501 - 512
(2007/10/03)
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