The synthesis of α-N,N-dimethyl-1'-diphenylphosphinoferrocenylethylamine and related ligands
Routes to the title compound were explored based on the cleavage of -ferrocenophanes with aryllithium.Thus the cleavage of (ν5-C5H4)Fe(ν5-C5H3(CHMeNMe2)PPh) with phenyllithium affords (ν5-C5H4Li)Fe(ν5-C5H3(CHMeNMe2)PPh2) and (ν5-C5H4PPh2)Fe(ν5-C5H3Li(CHMeNMe2)) in the ratio 15:85.Hydrolysis of this mixture affords the title compound 4.The lithio-ferrocenes can be treated with XER2 to yield other mixed ligands (E = As, P).A route to 4 via (ν5-C5H4PPh2)Fe(ν5-C5H4C(O)Me) was also established but it is complicated by low yields and many side products such as 5-C5H4PPh2)Fe(ν5-C5H4)>2C=CH2.
Butler, Ian R.,Cullen, William R.
p. 147 - 153
(2007/10/02)
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