-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines
A [3 + 2]-annulation of gem-difluoroalkenes and pyridinium ylides was developed employing ambient air as the sole oxidant in an open-vessel manner, affording a series of multifunctionalized 2-fluoroindolizines in moderate to good yields. In this reaction, gem-difluoroalkene acts as a C2 synthon and entirely avoids the competitive addition-elimination process, which provides facile access to 2-fluoroindolizines.
Zhang, Jun-Qi,Hu, Dandan,Song, Jinyu,Ren, Hongjun
p. 4646 - 4660
(2021/04/06)
Indolizines Enabling Rapid Uncaging of Alcohols and Carboxylic Acids by Red Light-Induced Photooxidation
The irradiation of red light-emitting-diode light (λ = 660 nm) to 3-acyl-2-methoxyindolizines in the presence of a catalytic amount of methylene blue triggered the photooxidation of the indolizine ring, resulting in a nearly quantitative release of alcohols or carboxylic acids within a few minutes. The method was applicable for photouncaging various functional molecules such as a carboxylic anticancer drug and a phenolic fluorescent dye from the corresponding indolizine conjugates, including an insulin-indolizine-dye conjugate.
Application of pyrazole-containing indolizine compound to preparation of anti-tumor drug
The invention belongs to the technical field of biochemical pharmacy, and particularly relates to an application of an indolizine compound with the chemical name of 5-methyl-1-cyano-3-(3, 5-dimethyl pyrazole carbonyl) to preparation of an anti-tumor drug. The indolizine compound shows good anti-tumor activity in in-vivo experiments and can be prepared into the drug for treating tumors which are tongue cancers or osteosarcoma or esophagus cancers or breast cancers or colon cancers or lung cancers or liver cancers or prostate tumors or kidney cancers or ovarian cancers or uterus cancers or pancreatic cancers or bladder cancers or melanoma or laryngeal cancers or nasopharyngeal cancers.
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Paragraph 0015; 0016; 0017
(2019/10/02)
Microwave assisted Westphal condensation and its application to synthesis of sempervirine and related compounds
A concise synthesis of a potent lead in anticancer therapeutics, sempervirine, was achieved by one pot Westphal condensation, ester hydrolysis, and decarboxylation under microwave irradiation. The method was extended to the synthesis of several similar he
Chinta Rao,Saha, Sanjay,Raolji, Gajendra B.,Patro, Balaram,Risbood, Prabhaker,Difilippantonio, Michael J.,Tomaszewski, Joseph E.,Malhotra, Sanjay V.
supporting information
p. 487 - 490
(2013/02/25)
Fluorescent quinolizinium ionic liquids (salts) with unexpectedly high quantum yields up to >99%
Quinolizinium ionic liquids (salts) featuring an unbranched cation core have been prepared, characterized and found to show extremely high fluorescence quantum yields in solution (Φf > 99%, λem near 334 nm) and bright cyan fluorescence in molten state (λem near 465 nm).
Schmidpeter, A.,Bansal, R. K.,Karaghiosoff, K.,Steinmueller, F.,Spindler, C.
p. 349 - 354
(2007/10/02)
2-Methylpyridinium Salts as 1,4-Dinucleophiles. Quinolizinium Salts from the Westphal Condensation
Condensation of 2-methylpyridinium salts with 1,2-dicarbonyls in the presence of base, yielded 2,3-disubstituted quinolizinium compounds.Results obtained with different pyridinium substrates are discussed.
Alvarez-Builla, J.,Trigo, G. Gonzales,Ezquerra, J.,Fombella, M.E.
p. 681 - 685
(2007/10/02)
Preparation of Tetrahydroindolizines from Pyridinuim and Isoquinolinium Ylides
Carbonyl- and nitrile-stabilised pyridinium and cyclic azonium methylides condense with chalcones to form tetrahydroindolizines and analogous fused pyrrolidines.The stereochemistry is illuminated by 13C and 1H n.m.r. spectroscopy.Several incorrect literature structures are rectified.
Katritzky, Alan R.,Grzeskowiak, Nicholas E.,Alvarez-Builla, Julio
p. 1180 - 1185
(2007/10/02)
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