Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis
Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2- carboxamide (20) was found to be the most active compound in vitro with MICs of 5.48 μM against log-phase culture of MTB and also non-toxic up to 100 μM.
Research on nitro-derivatives of biological interest. XVI. Structure-activity relationships as protozoocidal, anthelmintic and molluscicidal agents in 2-benzamido 5-nitrothiazole series
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Cavier,Gayral,Guillaumel,et al.
p. 539 - 543
(2007/10/07)
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