Regio- And chemoselective multiple functionalization of chloropyrazine derivatives. Application to the synthesis of coelenterazine
Successive regio- and chemoselective metalations of chloropyrazines using TMPMgCl-LiCl and TMPZnCIIiCI furnish, after trapping with electrophiles, highly functionalized pyrazines in high yields. Application to a synthesis of coelenterazine, a bioluminescent natural product in jellyfish Aequorea victoria, in nine steps (9% overall yield) is reported.
Mosrin, Marc,Bresser, Tomke,Knochel, Paul
supporting information; experimental part
p. 3406 - 3409
(2009/12/01)
Highly efficient and flexible total synthesis of coelenterazine
A new total synthesis of the bioluminescent chromophore coelenterazine 1 is described.
Keenan, Martine,Jones, Keith,Hibbert, Frank
p. 323 - 324
(2007/10/03)
More Articles about upstream products of 56071-69-3