cas 56181-82-9, 3-(4'-Bromo[1,1'-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenol

A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity against five human tumor cell lines. A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.

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56181-82-9

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Chemical Properties

Appearance/Colour :Cream To Pale Solid Powder.

Boiling Point: 512.8 °C at 760 mmHg

Flash Point:263.9 °C

Density: 1.359 g/cm³

Solubility:Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig

Storage Temp.:-20°C Freezer

PKA: 14.15±0.40(Predicted)

PSA: 20.23000

LogP: 5.87950

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56181-82-9

Articles about 56181-82-9Total 1 be found

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Chemical Properties

Appearance/Colour :Cream To Pale Solid Powder.

Boiling Point: 512.8 °C at 760 mmHg

Flash Point:263.9 °C

Density: 1.359 g/cm3

Solubility:Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig

Storage Temp.:-20°C Freezer

PKA: 14.15±0.40(Predicted)

PSA: 20.23000

LogP: 5.87950

Global suppliers and manufacturers of 56181-82-9total 56 suppliers on LookChem

Density: 1.359 g/cm³