- Synthesis technology of cefazedone
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The invention discloses a synthesis technology of cefazedone. A compound II reacts with 7-ACA to prepare a compound III, and the compound III reacts with a compound IV to prepare the product cefazedone (I). The technology has the advantages of simple synthesis route, mild reaction conditions, shortening of the reaction period, reduction of the production cost, increase of the total yield and the purity of the product, and suitableness for industrial production.
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Paragraph 0043-0051
(2019/11/21)
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- Cefazedone synthesis method
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The invention discloses a cefazedone synthesis method. A compound II reacts with 7-ACA to prepare a compound III, and the compound III reacts with a compound IV to prepare the final product cefazedone. The method has the advantages of simple reaction process, easiness in operation, high total yield and high purity of the product, few byproducts, and suitableness for industrial production.
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Paragraph 0033-0041
(2019/12/25)
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- Preparation method of cefazedone
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The invention discloses a preparation method of cefazedone. A starting material 7-amino acetoxyl-removed cepham acid (II) reacts with 3,5-dichloro pyridone acetate (III) to prepare a compound IV, the compound IV performs substitution reaction to obtain a compound V, the compound V reacts with 2-sulfydryl-5-methyl-1,3,4-thiadiazole to obtain a final product cefazedone. The cheap starting material reacts with a condensing agent, the reaction process is controllable, the operation is simple, the purity and the yield are high, and the method is suitable for industrial production.
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Paragraph 0013; 0014; 0046; 0047; 0048; 0049; 0050-0054
(2017/08/29)
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