- Preparation method of beta-alanyl-L-histidine
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The invention relates to the technical field of polypeptide synthesis, in particular to a preparation method of beta-alanyl-L-histidine. The preparation method of the beta-alanyl-L-histidine provided by the invention comprises the following steps: carrying out a reaction on beta-alanine and solid triphosgene to prepare 1, 3-oxazinane-2, 6-diketone, and then carrying out ring opening to prepare the beta-alanyl-L-histidine. The route of the method is shortened to two steps, the raw material conversion rate is high, the post-treatment is simple, and the purity of the obtained product is high.
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Paragraph 0039-0061
(2022/03/27)
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- METHOD OF SYNTHESIZING N-CARBOXYANHYDRIDE USING FLOW REACTOR
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PROBLEM TO BE SOLVED: To provide a synthesis method that allows high-yield continuous production of a compound of interest in synthesis and production of N-carboxyanhydride (NCA) and the like using a flow reactor. SOLUTION: In a synthesis method using a flow reactor 100, a basic solution adjusted in advance to a pH of 7-14 becomes acidic with a pH of 0-7, or an acidic solution adjusted in advance to a pH of 0-7 becomes basic with a pH of 7-14, within 60 seconds after the start of mixture of at least two ingredient solutions. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT
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Paragraph 0158-0160; 0162-0163
(2020/03/26)
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- Single-Step, Rapid, and Mild Synthesis of β-Amino Acid N-Carboxy Anhydrides Using Micro-Flow Technology
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β-Amino acid N-carboxy anhydrides (β-NCAs) are rarely used in the synthesis of β-peptides, which is due mainly to the poor availability of these potentially useful substrates. Herein, we describe the heretofore challenging synthesis of β-NCAs via a single
- Sugisawa, Naoto,Otake, Yuma,Nakamura, Hiroyuki,Fuse, Shinichiro
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- Simultaneous assembly of the β-lactam and thiazole moiety by a new multicomponent reaction
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A novel multicomponent reaction of β-aminothiocarboxylic acids, aldehydes, and 3-dimethylamino-2-isocyanoacylate is described. During the course of this reaction two heterocyclic moieties, a thiazole and a β-lactam ring, are formed simultaneously and under mild conditions. The increase in molecular complexity here is dramatic as 2 C-N, 2 C-S and 1 C-C bonds are formed in a new 'one-pot' multicomponent reaction.
- Kolb, Jürgen,Beck, Barbara,D?mling, Alexander
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p. 6897 - 6901
(2007/10/03)
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- Urethane N-carboxyanhydrides from β-amino acids
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A general method has been developed for the synthesis of N-tert-butyloxycarbonyl N-carboxyanhydrides from β-amino acids using Vilsmeier complex. These β-UNCA are stable, and the reactivity with different nucleophiles (alcohol, amine, lithium enolate) was studied.
- McKiernan,Huck,Fehrentz,Roumestant,Viallefont,Martinez
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p. 6541 - 6544
(2007/10/03)
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