Asymmetric synthesis of 2-arylpyrrolidines starting from γ-chloro N-(tert-butanesulfinyl)ketimines
The enantioselective reductive cyclization of γ-chloro N-(tert-butanesulfinyl)ketimines towards the short and efficient synthesis of (S)- and (R)-2-arylpyrrolidines (ee >99%) is described for the first time by treatment with LiBEt3H and subsequ
Enantioselective, thiourea-catalyzed intermolecular addition of indoles to cyclic N-acyl iminium ions
-
Peterson, Emily A.,Jacobsen, Eric N.
supporting information; experimental part
p. 6328 - 6331
(2009/12/01)
Stereoselective synthesis of 2-substituted pyrrolidines
Using O-pivaloyl protected D-galactopyranosylamine and D-arabinopyranosylamine, (S) or (R) configured α-substituted homoallylamines are synthesized with high diastereoselectivity by reaction of the corresponding aldimines with allyltributylstannane. Electrophile-induced endo-trig-cyclization of these N-glycosylhomoallylamines gave the 2-substituted pyrrolidines of high diastereomeric purity.
Deloisy, Sandrine,Tietgen, Heiko,Kunz, Horst
p. 816 - 828
(2007/10/03)
More Articles about upstream products of 56523-58-1