- Industrial production method of 3-trifluoromethyl-2-cyclohexene-1-one
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The invention relates to an industrial production method of 3-trifluoromethyl-2-cyclohexene-1-one, which is prepared from 1, 3-cyclohexanedione through iodination and trifluoromethylation, has obviously higher yield than the prior art, does not need special reaction conditions such as high temperature, high pressure and the like, does not involve the use of heavy metal pollution reagents, and has the advantages of simple reaction and post-treatment and low cost. The product is easy to purify and suitable for industrial production.
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Paragraph 0027-0029; 0033-0036
(2021/04/21)
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- Diastereo- and Enantioselective Cross-Couplings of Secondary Alkylcopper Reagents with 3-Halogeno-Unsaturated Carbonyl Derivatives
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Chiral secondary alkylcopper reagents were prepared from the corresponding alkyl iodides with retention of configuration by an I/Li-exchange using tBuLi (?100 °C, 1 min) followed by a transmetalation with CuBr?P(OEt)3 (?100 °C, 20 s). These ste
- Kremsmair, Alexander,Skotnitzki, Juri,Knochel, Paul
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supporting information
p. 11971 - 11973
(2020/09/07)
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- 3,4-DISUBSTITUTED 3-CYCLOBUTENE-1,2-DIONES AND USE THEREOF
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Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.
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Paragraph 0544; 0545
(2019/02/24)
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- Palladium-Catalyzed Ullmann Cross-Coupling of β-Iodoenones and β-Iodoacrylates with o-Halonitroarenes or o-Iodobenzonitriles and Reductive Cyclization of the Resulting Products to Give Diverse Heterocyclic Systems
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The palladium-catalyzed Ullmann cross-coupling of β-iodoenones and β-iodoacrylates such as 5 (X = I) with o-halonitroarenes and o-iodobenzonitriles including 2 affords products such as compound 7. These can be engaged in a range of reductive cyclization r
- Khan, Faiyaz,Dlugosch, Michael,Liu, Xin,Khan, Marium,Banwell, Martin G.,Ward, Jas S.,Carr, Paul D.
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supporting information
p. 2770 - 2773
(2018/05/22)
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- Synthesis of β-chloro, β-bromo, and β-iodo α,β-unsaturated ketones
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A new, efficient method for the preparation of β-chloro, β-bromo, and β-iodo α,β-unsaturated ketones is described.The method involves the reaction of β-diketones or α-hydroxymethylenecycloalkanones with triphenylphosphine dihalides in the presence of trie
- Piers, Edward,Grierson, John R.,Lau, Cheuk Kun,Nagakura, Isao
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p. 210 - 223
(2007/10/02)
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