Combinatorial Evolution of Fast-Conducting Highly Selective K+-Channels via Modularly Tunable Directional Assembly of Crown Ethers
We describe here a modularly tunable molecular strategy for construction and combinatorial optimization of highly efficient K+-selective channels. In our strategy, a highly robust supramolecular H-bonded 1D ensemble was used to order the appended crown ethers in such a way that they roughly stack on top of each other to form a channel for facilitated ion transport across the membrane. Among 15 channels that all prefer K+ over Na+ ions, channel molecule 5F8 shows the most pronounced optimum for K+ while disfavoring all other biologically important cations (e.g., Na+, Ca2+ and Mg2+). With a K+/Na+ selectivity of 9.8 and an EC50 value of 6.2 μM for K+ ion, 5F8 is clearly among the best synthetic potassium channels developed over the past decades.
Ren, Changliang,Shen, Jie,Zeng, Huaqiang
supporting information
p. 12338 - 12341
(2017/09/23)
Syntheses of cis- and trans-dibenzo-30-crown-10 derivatives via regioselective routes and their complexations with paraquat and diquat
(Chemical Equation Presented) cis-Dibenzo-30-crown-10 (cis-DB30C10) diester and trans-dibenzo-30-crown-10 (trans-DB30C10) diester were synthesized regioselectively with reasonable yields. These two isomers were further reduced to cis-dibenzo-30-crown-10 d
Benzo-15-crown-5 Derivatives. Synthesis and Properies as Ion-extraction and Ion-transport Agents
The preparation of some derivatives of benzo-15-crown-5 is described, each containing a carbohydrate moiety attached through either an ester or an ether linkage.The ion-extraction properties into dichloromethane of these and other related benzo-15-crown-5
Haines, Alan H.,Hodgkisson, Ian,Smith, Christopher
p. 311 - 318
(2007/10/02)
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