- A highly practical approach to chiral homoallylic-homopropargylic amines via aza-Barbier reaction
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The first access to chiral homoallylic-homopropargylic amine bearing two contiguous stereocenters has been well accomplished via zinc-promoted aza-Barbier reaction. N-tert-Butanesulfinyl ketimines are well-tolerated substrates, providing the tertiary amin
- Yuan, Bin-Hua,Zhang, Zhi-Cheng,Liu, Wen-Jie,Sun, Xing-Wen
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p. 2147 - 2151
(2016/05/02)
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- A new Co2(CO)8-mediated tandem [5 + 1]/[2 + 2 + 1]-cycloaddition reaction: A one-pot synthesis of tricyclic δ-lactones from cis-epoxy ene-ynes
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In the presence of Co2(CO)8 and CO, cis-epoxyalkynes bearing a tether olefin undergo a tandem [5 + 1]/[2 + 2 + 1]-cycloaddition to give tricyclic δ-lactones efficiently in a one-pot operation. The reaction mechanism is proposed to in
- Odedra, Arjan,Wu, Chang-Jung,Madhushaw, Reniguntala J.,Wang, Su-Lein,Liu, Rai-Shung
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p. 9610 - 9611
(2007/10/03)
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- Synthesis of annulated γ-carbolines and heteropolycycles by the palladium-catalyzed intramolecular annulation of alkynes
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A variety of N-substituted 2-bromo-1H-indole-3-carboxaldehydes incorporating an alkyne-containing tether on the indole nitrogen have been converted to the corresponding tert-butylimines, which have been subjected to palladium-catalyzed intramolecular imin
- Zhang, Haiming,Larock, Richard C.
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p. 5132 - 5138
(2007/10/03)
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- A stereoselective synthesis of (E)-1-halo-6,6-dimethyl-2-hepten-4-yne: A key intermediate for terbinafine
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A study of the stereoselective halogenation of 6,6-dimethyl-1-hepten-4- yn-3-ol (1) using a series of halogenating agents is described. Of the many agents investigated, boron trichloride is the most successful reagent for stereoselective halogenation (E:Z=9:1(max)). The resulting (E)-1-halo-6,6- dimethyl-2-hepten-4-yne (2), a key intermediate for terbinafine, an antifungal agent, is obtained in good yield and stereoselectivity. Two structurally related enyne alcohols have been studied likewise and shown similar versatility. (C) 2000 Elsevier Science Ltd.
- Chou, Shan-Yen,Tseng, Chin-Lu,Chen, Shyh-Fong
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p. 3895 - 3898
(2007/10/03)
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